1,2,3,4-tetrahydroisoquinoline derivatives

ABSTRACT

The invention relates to novel 1,2,3,4-tetrahydroisochinoline derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

[0001] The present invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of the general formula I and their use as pharmaceuticals. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of formula I, and especially their use as orexin receptor antagonists.

[0002] The orexins (hypocretins) comprise two neuropeptides produced in the hypothalamus: the orexin A (OX-A) (a 33 aminoacid peptide) and the orexin B (OX-B) (a 28 aminoacid peptide) (Sakurai T. et al., Cell, 1998, 92, 573-585). Orexins are found to stimulate food consumption in rats suggesting a physiological role for these peptides as mediators in the central feedback mechanism that regulates feeding behavior (Sakurai T. et al., Cell, 1998, 92, 573-585). On the other hand, it was also proposed that orexins regulate states of sleep and wakefulness opening potentially novel therapeutic approaches for narcoleptic patients (Chemelli R. M. et al., Cell, 1999, 98, 437-451). Two orexin receptors have been cloned and characterized in mammals which belong to the G-protein coupled receptor superfamily (Sakurai T. et al., Cell, 1998, 92, 573-585), the orexin-l receptor (OX₁) which is selective for OX-A and the orexin-2 receptor (OX₂) which is capable to bind OX-A as well as OX-B.

[0003] Orexin receptors are found in the mammalian host and may be responsible for many biological functions such as pathologies including, but not limited to, depression; anxiety; addictions; obsessive compulsive disorder; affective neurosis; depressive neurosis; anxiety neurosis; dysthymic disorder; behaviour disorder; mood disorder; sexual dysfunction; psychosexual dysfunction; sex disorder; schizophrenia; manic depression; delerium; dementia; severe mental retardation and dyskinesias such as Huntington's disease and Tourette syndrome; feeding disorders such as anorexia, bulimia, cachexia and obesity; diabetes; appetite/taste disorders; vomiting/nausea; asthma; cancer; Parkinson's disease; Cushing's syndrome/disease; basophil adenoma; prolactinoma; hyperprolactinemia; hypopituitarism; hypophysis tumor/adenoma; hypothalamic diseases; inflammatory bowel disease; gastric diskinesia; gastric ulcus; Froehlich's syndrome; adrenohypophysis disease; hypophysis disease; pituitary growth hormone; adrenohypophysis hypofunction; adrenohypophysis hyperfunction; hypothalamic hypogonadism; Kallman's syndrome (anosmia, hyposmia); functional or psychogenic amenorrhea; hypopituitarism; hypothalamic hypothyroidism; hypothalamic-adrenal dysfunction; idiopathic hyperprolactinemia; hypothalamic disorders of growth hormone deficiency; idiopathic growth deficiency; dwarfism; gigantism; acromegaly; disturbed biological and circadian rhythms; sleep disturbances associated with deseases such as neurological disorders, neuropathic pain and restless leg syndrome; heat and lung diseases, acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardinal infarction; ischaemic or haemorrhagic stroke; subarachnoid haemorrhage; ulcers; allergies; benign prostatic hypertrophy; chronic renal failure; renal disease; impaired glucose tolerance; migraine; hyperalgesia; pain; enhanced or exaggerated sensitivity to pain such as hyperalgesia, causalgia, and allodynia; acute pain; burn pain; a typical facial pain; neuropathic pain; back pain; complex regional pain syndrome I and II; arthritic pain; sports injury pain; pain related to infection e.g. HIV, post-chemotherapy pain; post-stroke pain; post-operative pain; neuralgia; conditions associated with visceral pain such as irritable bowel syndrome, migraine and angina; urinary bladder incontinence e.g. urge incontinence; tolerance to narcotics or withdrawal from narcotics; sleep disorders; sleep apnea; narcolepsy; insomnia; parasomnia; jet-lag syndrome; and neurodegerative disorders including nosological entities such as disinhibition-dementia-parkinsonism-amyotrophy complex; pallido-ponto-nigral degeneration epilepsy; seizure disorders and other diseases related to orexin.

[0004] The present invention provides 1,2,3,4-tetrahydroisoquinoline derivatives which are non-peptide antagonists of human orexin receptors, in particular OX₁ receptors. In particular, these compounds are of potential use in the treatment of obesity and/or sleep disorders.

[0005] So far not much is known about low molecular weight compounds which have a potential to antagonise either specifically OX₁ or OX₂ or both receptors at the same time. Recently WO 9909024 has been published wherein phenylurea and phenylthiourea derivatives as OX₁ antagonists are disclosed. Also quite recently WO 9958533 has been published disclosing the same type of compounds which are again

[0006] described as being preferably OX₁ receptor antagonists. The novel compounds of the present invention belong to an entirely different class of low molecular weight compounds as compared to all prior art orexin receptor antagonists so far published.

[0007] The present invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of the general formula (I).

[0008] wherein:

[0009] R¹, R², R³, R⁴ independently represent cyano, nitro, halogen, hydrogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, trifluoromethyl, trifluoromethoxy, cycloalkyloxy, aryloxy, aralkyloxy, heterocyclyloxy, heterocyclylalkyloxy, R¹¹CO—, NR¹²R¹³CO—, R¹²R¹³N—, R¹¹OOC—, R¹¹SO₂NH— or R¹⁴—CO—NH— or R² and R³ together as well as R¹ and R² together and R³ and R⁴ together may form with the phenyl ring a five, six or seven-membered ring containing one or two oxygen atoms;

[0010] R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰ independently represent hydrogen, aryl, aralkyl, lower alkyl, lower alkenyl, trifluoromethyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl;

[0011] R¹¹ represents lower alkyl, aryl, aralkyl, heterocyclyl or heterocyclyl-lower alkyl;

[0012] R¹² and R¹³ independently represent hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or heterocyclyl-lower alkyl;

[0013] R¹⁴ represents alkyl, aryl, cycloalkyl, heterocyclyl, R¹²R¹³N— or R¹¹O—.

[0014] The compounds of formula I can contain one or more asymmetric centres and can be present in the form of optically pure enantiomers, mixtures of enantiomers such as, for example, racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diastereoisomeric racemates, mixture of diastereoisomeric racemates, or meso forms and pharmaceutically acceptable salts thereof.

[0015] In the present description the term “lower alkyl”, alone or in combination, signifies a straight-chain or branched-chain alkyl group with 1 to 8 carbon atoms, preferably a straight or branched-chain alkyl group with 1-5 carbon atoms. Examples of straight-chain and branched C₁-C₈ alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, pentyl, hexyl, heptyl, octyl, isobutyl tert-butyl, the isomeric pentyls, the isomeric hexyls, the isomeric heptyls and the isomeric octyls, preferably methyl, ethyl, propyl, isopropyl, butyl, 2-butyl, tert-butyl and pentyl.

[0016] The term “lower alkenyl”, alone or in combination, signifies a straight-chain or branched-chain alkenyl group with 2 to 5 carbon atoms, preferably allyl and vinyl.

[0017] The term “lower alkoxy”, alone or in combination, signifies a group of the formula alkyl-O— in which the term “alkyl” has the previously given significance, such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, preferably methoxy and ethoxy.

[0018] Lower alkenyloxy groups are preferably vinyloxy and allyloxy.

[0019] The term “cycloalkyl”, alone or in combination, signifies a cycloalkyl ring with 3 to 8 carbon atoms and preferably a cycloalkyl ring with 3 to 6 carbon atoms. Examples of C₃-C₈ cycloalkyl are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl, preferably cyclopropyl, cyclohexyl and particularly cyclohexyl or lower alkyl substituted cycloalkyl which may preferably be substituted with lower alkyl such as methyl-cyclopropyl, dimethyl-cyclopropyl, methyl-cyclobutyl, methyl-cyclopentyl, methyl-cyclohexyl, dimethyl-cyclohexyl,

[0020] The term “aryl”, alone or in combination, signifies a phenyl or naphthyl group which optionally carries one or more substituents, preferably one or two substituents, each independently selected from cyano, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, trifluoromethyl, trifluoromethoxy, amino, carboxy and the like, such as phenyl, p-tolyl, 4-methoxyphenyl, 4-tert-butoxyphenyl 4-fluorophenyl, 2-chlorophenyl, 4-hydroxyphenyl, 1-naphthyl and 2-naphthyl. Preferred are carboxyphenyl, lower alkoxy-phenyl, hydroxyphenyl and particularly phenyl.

[0021] The term “aralkyl”, alone or in combination, signifies an alkyl or cycloalkyl group as previously defined in which one hydrogen atom has been replaced by an aryl group as previously defined. Preferred are benzyl and benzyl substituted in the phenyl ring with hydroxy, lower alkyl, lower alkoxy or halogen preferably chlorine. Particularly preferred is benzyl.

[0022] For the term “heterocyclyl” and “heterocyclyl-lower alkyl”, the heterocyclyl group is preferably a 5- to 10-membered monocyclic or bicyclic ring, which may be saturated, partially unsaturated or aromatic containing for example 1, 2 or 3 heteroatoms selected from oxygen, nitrogen and sulphur which may be the same or different. Example of such heterocyclyl groups are pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, pyridyl pyrimidinyl, pyrazinyl, pyridazinyl, quinolyl, isoquinolyl, thienyl, thiazolyl, isothiazolyl, furyl, imidazoyl, pyrazolyl, pyrrolyl, indazolyl, indolyl, isoindolyl, isoxazolyl, oxazolyl, quinoxalinyl, phthalazinyl, cinnolinyl, dihydropyrrolyl, pyrrolidinyl, isobenzofuranyl, tetrahydrofuranyl, dihydropyranyl. The heterocyclyl group may have up to 5, preferably 1, 2 or 3 optional substituents. Examples of suitable substituents include halogen, lower allyl, amino, nitro, cyano, hydroxy, lower alkoxy, carboxy and lower alkyloxy-carbonyls.

[0023] The term “halogen” signifies fluorine, chlorine, bromine or iodine and preferably chlorine and bromine and particularly chlorine.

[0024] The term “carboxy”, alone or in combination, signifies a —COOH group.

[0025] A group of preferred compounds according to the present invention are compounds of formula (I) wherein R², R³, R⁶, R⁷, R⁸ and R⁹ are hydrogen. Examples of preferred compounds are:

[0026] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0027] 2-[1-(3,4-dimethoxy-benzyl)-8-(cyclopropyl-methoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0028] 2-[1-(3,4-dimethoxy-benzyl)-8-(2-fluoro-ethoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0029] 2-[1-(3,4-dimethoxy-benzyl)-8-(2,2-difluoro-ethoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0030] 2-[1-(3,4-dimethoxy-benzyl)-8-ethoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0031] 2-[1-(3,4-dimethoxy-benzyl)-8-propoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0032] 2-[1-(3,4-dimethoxy-benzyl)-8-allyloxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0033] 2-[1-(3,4-dimethoxy-benzyl)-8-isopropoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0034] 2-[1-(3,4-dimethoxy-benzyl)-5-propoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0035] Another group of preferred compounds according to the present invention are compounds of formula (II)

[0036] wherein:

[0037] R′¹ and R′² independently represent hydrogen, hydroxy, alkoxy, heteroaryloxy, carbamoyloxy or halogen or may form with the phenyl ring a five, six or seven membered-ring containing one or two oxygen atoms,

[0038] R′³, R′⁴, R′⁵ independently represent aryl, aralkyl, lower alkyl, lower alkenyl trifluoromethyl, cycloallyl, heterocyclyl or heterocyclyl-lower alkyl.

[0039] The compounds of formula (II) can contain one or more asymmetric centres and can be present in the form of optically pure enantiomers, mixtures of enantiomers such as, for example, racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diastereoisomeric racemates, mixture of diastereoisomeric racemates, or meso forms and pharmaceutically acceptable salts thereof

[0040] Examples of preferred compounds of formula (II) are:

[0041] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0042] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-naphthalen-1-ylmethyl-acetamide

[0043] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide

[0044] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-fluoro-benzyl)-acetamide

[0045] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-naphthalen-2-ylmethyl)-acetamide

[0046] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methoxy-naphthalen-2-ylmethyl)-acetamide

[0047] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3,6)-difluoro-benzyl)-acetamide

[0048] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1-phenyl-ethyl)-acetamide

[0049] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-ylmethyl)-acetamide

[0050] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-benzyl)-acetamide

[0051] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-benzyl)-acetamide

[0052] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0053] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide

[0054] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(pyrazin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0055] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(thiazol-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0056] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-methoxy-indan-1-yl)-acetamide

[0057] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide

[0058] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide

[0059] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide

[0060] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-indan-1-yl)-acetamide

[0061] 2-[1-(3,4-Dimethoxy-benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide

[0062] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide

[0063] 2-{-[4-(pyrimidin-2-yloxy)-3-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide

[0064] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(N,N-dimethylcarbamoyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0065] 2-[1-(3,4-dimethoxy-benzyl)-7-(3-fluoro-propoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0066] 2-[1-(3,4-dimethoxy-benzyl)-7-(2-fluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0067] 2-[1-(3,4-dimethoxy-benzyl)-7-(2,2-difluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0068] 2-[1-(3,4-dimethoxy-benzyl)-7-(but-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0069] 2-[1-(3,4-dimethoxy-benzyl)-7-(cyclopropyl-methoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0070] 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0071] 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0072] 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0073] 2-[1-(3,4-dimethoxy-benzyl)-7-isopropoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0074] 2-[1-(3,4-dimethoxy-benzyl)-7-(1-methyl-prop-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0075] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide

[0076] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0077] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin 2-yl]-N-[(1S)-indan-1-yl]-acetamide

[0078] 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0079] 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0080] 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0081] N-benzyl-2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide

[0082] 2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide

[0083] N-benzyl-2-[-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-H-isoquinolin-2-yl]-acetamide

[0084] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide

[0085] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide

[0086] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-4-yl-methyl)-acetamide

[0087] 2-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide

[0088] Examples of particularly preferred compounds of formula (II) are:

[0089] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0090] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-naphthalen-1-ylmethyl-acetamide

[0091] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0092] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide

[0093] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-pyrazin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0094] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(thiazol-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0095] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-methoxy-indan-1-yl)-acetamide

[0096] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide

[0097] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide

[0098] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide

[0099] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-indan-1-yl)-acetamide

[0100] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide

[0101] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide

[0102] 2-{1-[4-(pyrimidin-2-yloxy)-3-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide

[0103] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(N,N-dimethylcarbamoyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0104] 2-[1-(3,4-dimethoxy-benzyl)-7-(3-fluoro-propoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0105] 2-[1-(3,4-dimethoxy-benzyl)-7-(2-fluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0106] 2-[1-(3,4-dimethoxy-benzyl)-7-(2,2-difluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0107] 2-[1-(3,4-dimethoxy-benzyl)-7-(but-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0108] 2-[1-(3,4-dimethoxy-benzyl)-7-(cyclopropyl-methoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0109] 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0110] 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0111] 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0112] 2-[1-(3,4-dimethoxy-benzyl)-7-isopropoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[0113] 2-[1-(3,4-dimethoxy-benzyl)-7-(1-methyl-prop-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0114] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide

[0115] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0116] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide

[0117] 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0118] 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0119] 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0120] N-benzyl-2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide

[0121] 2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide

[0122] N-benzyl-2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide

[0123] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide

[0124] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide

[0125] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-4-yl-methyl)-acetamide

[0126] 2-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide

[0127] Examples of physiologically usable or pharmaceutically acceptable salts of the compounds of formula (I) are salts with physiologically compatible mineral acids such as hydrochloric acid, sulphuric or phosphoric acid; or with organic acids such as methanesulphonic acid, acetic acid, trifluoroacetic acid, citric acid, fumaric acid, maleic acid, tartaric acid, succinic acid or salicylic acid. The compounds of formula (I) with free carboxy groups can also form salts with physiologically compatible bases.

[0128] Examples of such salts are alkali metal, alkali earth metal, ammonium and alkylammoniumsalts such as Na, K, Ca or tetraalkylammonium salt. The compounds of formula (I) can also be present in the form of a zwitterion.

[0129] The compounds of formula (I) can contain several asymmetric centres and can be present in the form of optically pure enantiomers, mixtures of enantiomers such as, for example, racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diasteroisomeric racemates or mixtures of diastereoisomeric racemates and the meso-forms.

[0130] Preferred compounds as described above have IC₅₀ values below 1000 nM; especially preferred compounds have IC₅₀ values below 100 nM which have been determinated with the FLIPR (Fluorometric Imaging Plates Reader) method described in the beginning of the experimental section.

[0131] The compounds of the general formula (I) and their pharmaceutically usable salts can be used for the treatment of diseases or disorders where an antagonist of a human orexin receptor is required such as obesity, diabetes, prolactinoma, narcolepsy, insomnia, sleep apnea, parasomnia, depression; anxiety, addictions, schizophrenia and dementia.

[0132] The compounds of formula (I) and their pharmaceutically usable salts are particularly useful for the treatment of obesity and sleep disorders.

[0133] The compounds of formula (I) and their pharmaceutically usable salts can be used as medicament (e.g. in the form of pharmaceutical preparations). The pharmaceutical preparations can be administered internally, such as orally (e.g. in the form of tablets, coated tablets, dragées, hard and soft gelatine capsules, solutions, emulsions or suspensions), nasally (e.g. in the form of nasal sprays) or rectally (e.g. in the form of suppositories). However, the administration can also be effected parentally, such as intramuscularly or intravenously (e.g. in the form of injection solutions).

[0134] The compounds of formula (I) and their pharmaceutically usable salts can be processed with pharmaceutically inert, inorganic or organic adjuvants for the production of tablets, coated tablets, dragées, and hard gelatine capsules. Lactose, corn starch or derivatives thereof, talc, stearic acid or its salts etc. can be used, for example, as such adjuvants for tablets, dragées, and hard gelatine capsules.

[0135] Suitable adjuvants for soft gelatine capsules, are, for example, vegetable oils, waxes, fats, semi-solid substances and liquid polyols, etc.

[0136] Suitable adjuvants for the production of solutions and syrups are, for example, water, polyols, saccharose, invert sugar, glucose, etc.

[0137] Suitable adjuvants for injection solutions are, for example, water, alcohols, polyols, glycerol, vegetable oils, etc.

[0138] Suitable adjuvants for suppositories are, for example, natural or hardened oils, waxes, fats, semi-solid or liquid polyols, etc.

[0139] Morever, the pharmaceutical preparations can contain preservatives, solubilizers, viscosity-increasing substances, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances. The invention also relates to processes for the preparation of compounds of Formula I.

[0140] The compounds of general formula (I) of the present invention are prepared according to the general sequence of reactions outlined in the schemes below, wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R¹⁰ are as defined in formula (I) above. As the case may be any compound obtained with one or more optically active carbon atom may be resolved into pure enantiomers or diastereomers, mixtures of enantiomers or diastereomers, diastereomeric racemates and the meso-forms in a manner known per se.

[0141] The compounds obtained may also be converted into a pharmaceutically acceptable salt thereof in a manner known per se.

[0142] The compounds of formula (I) may be prepared as single compounds or as libraries of compounds comprising at least 2, e.g. 5 to 1000 compounds of formula (I).

[0143] Compound libraries may be prepared by a combinatorial approach or by multiple parallel synthesis using solution phase chemistry.

[0144] For the combinatorial approach, the compounds of general formula (I) wherein R⁶, R⁷, R⁹ are hydrogen, are prepared using an Ugi-three-components-condensation reaction (Ugi-3-CC) which involves the one-pot reaction between a 1,2,3,4-tetrahydroisoquinoline derivative, an aldehyde and an isocyanide (Scheme 1).

[0145] Isocyanides not commercially available might be prepared from the corresponding amines by N-formylation followed by treatment with POCl₃ (see e.g. J. March, fourth edition, Wiley-Interscience publication, p. 1042).

[0146] The compounds of the general formula (I) wherein R⁶ and R⁷ are hydrogen, may also be prepared by different procedures. The synthetic route depends on the last chemical transformation which has to be carried out.

[0147] In all cases in which the coupling of the tetrahydroisoquinoline with the amide side-chain is the final step the standard procedure shown in (Scheme 2) was followed. The tetrahydroisoquinolines as well as the amines (R⁹R¹⁰NH) could be either commercially available or synthesized.

[0148] Tetrahydroisoquinolines not commercially available might be prepared from the corresponding phenylethylamines by coupling with the desired carboxylic acid followed by treatment with POCl₃ and finally NaBH₄ (see experimental part). All aminoindan-derivatives were prepared by reaction of 1-indanones with O-methylhydroxylamine followed by reduction with borane-tetrahydrofuran complex (Vaccaro W. et al., J. Med. Chem., 1996, 39, 1704-1719).

[0149] Compounds of general formula (I) wherein one substituent of the 1-benzyl-tetrahydroisoquinoline scaffold is a carbamoyloxy-, heteroaryloxy- or alkoxy-residue (not methoxy) are synthesized according to (Scheme 3). The benzyl-protected phenols are prepared by the procedure shown in (Scheme 2).

[0150] In the case R⁵ (general formula I) is a heterocyclyl-methyl substituent the final step is the substitution of a mesylate function with the corresponding nitrogen containing nucleophile according to (Scheme 4). The required starting material was synthesized by the same procedure as described earlier (Scheme 2).

[0151] Stereochemically pure compounds of general formula I are obtained by kinetic resolution of the tetrahydroisoquinoline (Corrodi H., Hardegger E., Helv. Chim. Acta, 1956, 39, 889-897) and coupling of the pure enantiomer with the amide linker according to Scheme 2. Furthermore 2-[(1S)-1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide could also be obtained by crystallization of the diastereoisomeric mixture of the two 2-{1[R,S]-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-[(1S)-indan-1-yl]-acetamides from methanol.

[0152] Experimental Section

[0153] I. Biology

[0154] Determination of OX₁ Receptor Antagonist Activity

[0155] The OX₁ receptor antagonist activity of the compounds of formula (I) was determinated in accordance with the following experimental method.

[0156] Experimental Method:

[0157] Intracellular Calcium Measurements

[0158] Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, were grown in culture medium (Ham F-12 with L-Glutamine) containing 300 μg/ml G418, 100 U/ml penicillin, 100 μg/ml streptomycin and 10% inactivated foetal calf serum (FCS).

[0159] The cells were seeded at 80,000 cells/well into 96-well black clear bottom sterile plates (Costar) which had been precoated with 1% gelatine in Hanks' Balanced Salt Solution (HBSS). All reagents were from Gibco BRL.

[0160] The seeded plates were incubated overnight at 37° C. in 5% CO₂.

[0161] Human orexin-A as an agonist was prepared as 1 mM stock solution in methanol:water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA) and 2 mM HEPES for use in the assay at a final concentration of 10 nM.

[0162] Antagonists were prepared as 10 mM stock solution in DMSO, then diluted in 96-well plates, first in DMSO, then in HBSS containing 0.1% bovine serum albumin (BSA) and 2 mM HEPES.

[0163] On the day of the assay, 100 μl of loading medium (HBSS containing 1% FCS, 2 mM HEPES, 5 mM probenecid (Sigma) and 3 μM of the fluorescent calcium indicator fluo-3 AM (1 mM stock solution in DMSO with 10% pluronic acid) (Molecular Probes) was added to each well.

[0164] The 96-well plates were incubated for 60 min at 37° C. in 5% CO₂. The loading solution was then aspirated and cells were washed 3 times with 200 μl HBSS containing 2.5 mM probenecid, 0.1% BSA, 2 mM HEPES. 100 μl of that same buffer was left in each well. Within the Fluorescent Imaging Plate Reader (FLIPR, Molecular Devices), antagonists were added to the plate in a volume of 50 μl, incubated for 20 min and finally 100 μl of agonist was added. Fluorescence was measured for each well at 1 second intervals, and the height of each fluorescence peak was compared to the height of the fluorescence peak induced by 10 nM orexin-A with buffer in place of antagonist. For each antagonist, IC₅₀ value (the concentration of compound needed to inhibit 50% of the agonistic response) was determined.

[0165] II. Chemistry

[0166] The following examples illustrate the preparation of pharmacologically active compounds of the invention but do not at all limit the scope thereof. All temperatures are stated in ° C.

[0167] All hydrochloride salts were prepared by dissolving the free-base in dichloromethane and treating with an excess of ethereal HCl (2M).

[0168] General Procedures:

[0169] A. General Procedure A:

[0170] 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid benzyl ester

[0171] To a white suspension of 1-(4,5-dimethoxybenzyl)6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-hydrochloride (1 g, 2.632 mmol) in a mixture of toluene/DMF (9/1) (10 ml), were added triethylamine (1.1 ml, 7.896 mmol) and chlorobenzylacetate (440 μl, 2.895 mmol). The reaction mixture was stirred at reflux under argon for 20 h. After cooling, the mixture was diluted in CH₂Cl₂ and washed with water.

[0172] The aqueous phase was extracted twice with CH₂Cl₂, the combined organic phases were dried over anhydrous MgSO₄, filtered and concentrated to give a crude brown-orange oil. Flash chromatography (AcOEt/hexane 1/1) gave 1.15 g (89%) of the title product as a brown-orange oil.

[0173] TLC (AcOEt/hexane: 1/1): R_(f)=0.55.

[0174] LC-MS (MeCN/H₂O: 1/1): R_(t)=4.16 min. m/z=492 (M+1).

[0175] 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid.

[0176] To a solution of 1-[(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid benzyl ester (1.15 g, 2.34 mmol) in dry AcOEt (20 ml) was added in one portion Pd-C 10% (250 mg). The resulting black suspension was hydrogenated at normal pressure and room temperature for 20 h. The mixture was then filtered over celite and concentrated in vacuo to give brown crystals.

[0177] LC-MS (MeCN/H₂O: 1/1): R_(t)=3.34 min. m/z=402 (M+1).

Example 1

[0178] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[0179] To a solution of 1-(4,5-dimethoxybenzyl)-6,7-dimethoxy-(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid (100 mg, 0.249 mmol) in 4 ml of dry DMF, were added 129.6 mg (0.249 mmol) of PyBOP, 29.9 μl (0.226 mmol) of benzylamine and dropwise 110 μl (0.521 mmol) of diisopropylethylamine (Hünig's base). The mixture reaction was stirred at RT under argon for 20 h. The mixture was then dissolved in CH₂Cl₂ and washed with water. The aqueous phase was extracted twice with CH₂Cl₂, the combined organic extracts were dried over MgSO₄, filtered and concentrated to give a crude brown residue. Flash chromatography (AcOEt/hexane 8/2) gave 126 mg (94%) of the title compound as a brown viscous oil.

[0180] TLC (AcOEt/hexane: 8/2): R_(f)=0.65.

[0181] LC-MS MeCN/H₂O: 1/1): R_(t)=4.83 min. m/z=491(M+1).

Example 2

[0182] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-naphthalen-1-ylmethyl-acetamide

[0183] In analogy to Example 1 but for the final step, reaction of 1-(4,5-dimethoxybenzyl)-6,7-dimethoxy-(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid with 1-naphthlalenemethylamine to give the title compound as the free-base (brown viscous oil) and the hydrochloride salt (brown crystals)

[0184] —TLC (AcOEt): R_(f)=0.55.

[0185] —LC-MS MeCN/H₂O: 1/1): R_(t)=5.97 min. m/z=541(M+1).

Example 3

[0186] 2-[1-(3,4-Dimethoxy-benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-naphthalen-2-ylmethyl)-acetamide

[0187] In analogy to Example 1 but for the final step, reaction of 1-(4,5-dimethoxybenzyl)-6,7-dimethoxy-(3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid with 6-methoxynaphthalene-2-methylamine to give the title compound as the free-base (brown oil).

[0188] —TLC (AcOEt): R_(f)=0.40 —LC-MS (MeCN/H₂O: 1/1): R_(t)=4.68 min. m/z=571(M+1).

[0189] 2-(3-Bromo-4-methoxy-phenyl)-N-[2-(3,4-dimethoxy)-ethyl]-acetamide

[0190] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.28 min, 409 (M+1, ES+).

[0191] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3,4-dimethyl-phenyl)-acetamide

[0192] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.36 min, 328 (M+1, ES+).

[0193] 2-(3,4-Diethyl-phenyl)-N-[2-(3,4-dimethoxy)-ethyl]-acetamide

[0194] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.18 min, 356 (M+1, ES+).

[0195] 2-(3,4-Dichloro-phenyl)-N-[2-(3,4-dimethoxy)-ethyl]-acetamide

[0196] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.12 min, 369 (M+1, ES+).

[0197] 1-(4-Bromo-3-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

[0198] LC-MS (MeCN/H₂O: 1/1): R_(t) 2.96 min, 393 (M+1, ES+).

[0199] 1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

[0200] LC-MS (MeCN/H₂O: 1/1): R_(t) 3.19 min, 312 (M+1, ES+).

[0201] 1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

[0202] LC-MS (MeCN/H₂O: 1/1): R_(t) 2.25 min, 340 (M+1, ES+).

[0203] 1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

[0204] LC-MS (MeCN/H₂O: 1/1): R_(t) 3.20 min, 353 (M+1, ES+).

[0205] 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid methyl ester

[0206] To a white suspension of 1-(4,5-dimethoxybenzyl)6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-hydrochloride (5 g, 0.013 mol) in dry toluene (50 ml), were added triethylamine (5.5 ml, 0.039 mol) and bromo-phenyl-acetic acid methyl ester (2.07 ml, 0.013 mol). The reaction mixture was stirred at reflux under argon for 20 h. After cooling, the mixture was diluted in CH₂Cl₂ and washed with water. The aqueous phase was extracted twice with CH₂Cl₂, the combined organic phases were dried over anhydrous MgSO₄, filtered and concentrated to give a crude brown-orange oil. Flash chromatography (AcOEt/hexane 1/1) gave 5.85 g (90%) of the title product as a brown-orange oil.

[0207] TLC (AcOEt/hexane: 1/1): R_(f)=0.55.

[0208] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.00 min and R_(t) 4.36 min, 492 (M+1, ES+).

[0209] 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid

[0210] To a solution of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid methyl ester (5.85 g, 0.011 mmol) in a mixture dioxane/MeOH (4/3) (160 ml) was added dropwise 2M NaOH_((aq)) (81 ml). The resulting mixture was stirred at RT for 20 h under nitrogen. The mixture was then concentrated in vacuo, combined with water and AcOEt. The aqueous phase was acidified until pH 1 with 2N HCl, extracted three times with with CH₂Cl₂, the combined organic phases were dried over anhydrous MgSO₄, filtered and concentrated to give the titled product (5.55 g, 97%) as yellow-green crystals.

[0211] LC-MS (MeCN/H₂O: 1/1): R_(t) 3.62 min and R_(t) 3.65 min, 478 (M+1, ES+).

Example 4

[0212] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-N-indan-1-yl-2-phenyl-acetamide:

[0213] To a solution of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid (100 mg, 0.209 mmol) in 5 ml of dry DMF, were added PyBOP (109 mg, 0.209 mmol), 1-aminoindane (32.3 mg, 0.19 mmol) and dropwise diisopropylethylamine (Hünig's base). (75 μl, 0.437 mmol). The mixture reaction was stirred at RT under argon for 20 h. The mixture was then dissolved in CH₂Cl₂ and washed with water. The aqueous phase was extracted twice with CH₂Cl₂, the combined organic extracts were dried over MgSO₄, filtered and concentrated to give a crude brown residue. Flash chromatography (AcOEt) gave 72 mg (64%) of the title compound as a pale brown oil.

[0214] TLC (AcOEt): R_(f)=0.65.

[0215] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.35 min and R_(t) 4.60 min, 593 (M+1, ES+).

Example 5

[0216] N-Butyl-2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-2-phenyl-acetamide

[0217] prepared by reaction of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid with n-butylamine.

[0218] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.09 min 533 (M+1, ES+).

[0219] 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-pyrimidin-acetic acid ethyl ester

[0220] To a white suspension of 1-(4,5-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-hydrochloride (1.65 g, 4.36 mmol) in dry DMF (5 ml), were added triethylamine (1.82 ml, 0.013 mol) and bromo-pyrimidin-acetic acid ethyl ester (1.07 g, 4.36 mmol). The reaction mixture was stirred at reflux under argon for 20 h. After cooling, the mixture was diluted in AcOEt and washed with water. The aqueous phase was extracted twice with CH₂Cl₂, the combined organic phases were dried over anhydrous AcOEt, filtered and concentrated to give a crude brown-orange oil. Flash chromatography (AcOEt) gave 1.4 g (63%) of the title product as a brown-orange oil.

[0221] TLC (AcOEt): R_(f)=0.55.

[0222] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.54 min and R_(t) 4.69 min, 508 (M+1, ES+).

[0223] 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-pyrimidin-acetic acid

[0224] To a solution of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-pyrimidin-acetic acid ethyl ester (1.4 g, 2.75 mmol) in a mixture dioxane/MeOH (4/3) (35 ml) was added dropwise 2M NaOH_((aq)) (24 ml). The resulting mixture was stirred at RT for 20 h under nitrogen. The mixture was then concentrated in vacuo, combined with water and AcOEt. The aqueous phase was acidified until pH 1 with 2N HCl, extracted three times with with CH₂Cl₂, the combined organic phases were dried over anhydrous MgSO₄, filtered and concentrated to give the titled product (1.23 g, 93%) as yellow-green crystals.

[0225] LC-MS (MeCN/H₂O: 1/1): R_(t) 3.11 min and R_(t) 3.24 min, 480 (M+1, ES+).

Example 6

[0226] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-2-N-indan-2-yl-2-pyrimidin-5-yl-acetamide

[0227] prepared by reaction of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-pyrimidin-acetic acid with 2-aminoindane hydrochloride.

[0228] LC-MS (MeCN/H₂O: 1/1): R_(t) 4.64 min and R_(t) 4.83 min, 595 (M+1, ES+).

Example 7

[0229] N-benzyl-2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide:

[0230] prepared by reaction of 1-(3,4-dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine.

[0231] LC-MS (MeCN/H₂O: 1/1): R_(t)=4.35 min, 459 (M+1, ES+).

Example 8

[0232] 2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-indan-1-yl-acetamide:

[0233] prepared by reaction of 1-(3,4-dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-aminoindane.

[0234] LC-MS (MeCN/H₂O: 1/1): R_(t)=4.47 min, 485(M+1, ES+).

Example 9

[0235] 2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-pyridin-2-yl-acetamide:

[0236] prepared by reaction of 1-(3,4-dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine.

[0237] LC-MS (MeCN/H₂O: 1/1): R_(t)=2.99 min, 460 (M+1, ES+).

Example 10

[0238] 2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-pyridin-3-yl-acetamide:

[0239] prepared by reaction of 1-(3,4-dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-picolylamine.

[0240] LC-MS (MeCN/H₂O: 1/1): R_(t)=2.61 min, 460 (M+1, ES+).

Example 11

[0241] N-benzyl-2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide:

[0242] prepared by reaction of 1-(3,4-diethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine.

[0243] LC-MS (MeCN/H₂O: 1/1): R_(t)=4.35 min, 459 (M+1, ES+).

Example 12

[0244] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0245] prepared by reaction of 1-(3,4-diethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine.

[0246] LC-MS (MeCN/H₂O: 1/1): R_(t)=2.87 min, 488 (M+1, ES+).

Example 13

[0247] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0248] prepared by reaction of 1-(3,4-diethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-picolylamine.

[0249] LC-MS (MeCN/H₂O: 1/1): R_(t)=2.85 min. 488 (M+1, ES+).

Example 14

[0250] 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-4-yl-methyl)-acetamide:

[0251] prepared by reaction of 1-(3,4-diethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-picolylamine.

[0252] LC-MS MeCN/H₂O: 1/1): R_(t)=2.71 min. 488 (M+1, ES+).

Example 15

[0253] 2-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl-acetamide:

[0254] prepared by reaction of 1-(3,4-dichloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine.

[0255] LC-MS (MeCN/H₂O: 1/1): R_(t)=3.72 min, 501 (M+1, ES+).

Example 16

[0256] 2-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0257] prepared by reaction of 1-(3,4-dichloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-picolylamine.

[0258] LC-MS (MeCN/H₂O: 1/1): R_(t)=3.29 min, 501 (M+1, ES+).

[0259] B Coupling of 1,2,3,4-Tetrahydroisoquinolines with 2-Bromoacetamides

[0260] B.1 Starting Materials: Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives:

[0261] B.1.1 Synthesis of the Phenylethylamides:

[0262] Procedure I:

[0263] A solution of the respective phenylethylamine (80 mmol) and of triethylamine (90 mmol) in THF (120 mL) was cooled to 0° C. and treated portionwise with the respective acetyl chloride (80 mmol). After stirring for 10 min at 0° C. and for 14 h at room temperature a sat. aqueous NaHCO₃ solution was added, the phases were separated and the aqueous phase was extracted three times with ethyl acetate (150 mL). The solvent was removed in vacuo and the residue was either recrystalized from toluene or purified by flash chromatography to give the following amides:

[0264] N-[2-(3-Methoxy-phenyl)-ethyl]-3,4-dimethoxyphenyl-acetamide:

[0265] prepared by reaction of 3-methoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0266] LC-MS: rt=4.1 min, 330 (M+1, ES+).

[0267] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-phenyl-acetamide:

[0268] prepared by reaction of 3,4-dimethoxyphenylethylamine with phenyl acetyl chloride.

[0269] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-methoxyphenyl-acetamide:

[0270] prepared by reaction of 3,4-dimethoxyphenylethylamine with 3-methoxyphenyl acetyl chloride.

[0271] LC-MS: rt=4.0 min, 330 (M+1, ES+).

[0272] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-methoxyphenyl-acetamide:

[0273] prepared by reaction of 3,4-dimethoxyphenylethylamine with 4-methoxyphenyl acetyl chloride.

[0274] LC-MS: rt=4.0 min, 330 (M+1, ES+).

[0275] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,5-dimethoxyphenyl-acetamide:

[0276] prepared by reaction of 3,4-dimethoxyphenylethylamine with 2,5-dimethoxyphenyl acetyl chloride.

[0277] LC-MS: rt=4.1 min, 360 (M+1, ES+).

[0278] N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-3,4-dimethoxyphenyl-acetamide:

[0279] prepared by reaction of 2,5-dimethoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0280] LC-MS: rt=4.2 min, 360 (M+1, ES+).

[0281] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-phenyl-propionamide:

[0282] prepared by reaction of 3,4-dimethoxyphenylethylamine with 3-phenyl propionyl chloride.

[0283] LC-MS: rt=4.2 min, 314 (M+1, ES+).

[0284] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-phenyl-butyramide:

[0285] prepared by reaction of 3,4-dimethoxyphenylethylamine with 2-Phenylbutyryl chloride.

[0286] R_(f)=0.21 (ethyl acetate/heptane 1/1)

[0287] N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-diphenyl-acetamide:

[0288] prepared by reaction of 2,5-dimethoxyphenylethylamine with diphenylacetyl chloride.

[0289] LC-MS: rt=5.3 min, 376 (M+1, ES+).

[0290] N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-2,5-dimethoxyphenyl-acetamide:

[0291] prepared by reaction of 2,5-dimethoxyphenylethylamine with 2,5-dimethoxyphenyl acetyl chloride.

[0292] LC-MS: rt=4.6 min, 360 (M+1, ES+).

[0293] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-chlorophenyl-acetamide:

[0294] prepared by reaction of 3,4-dimethoxyphenylethylamine with 4-chlorophenyl acetyl chloride.

[0295] LC-MS: rt=4.4 min, 334 (M+1, ES+).

[0296] N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-phenyl-acetamide:

[0297] prepared by reaction of 2,5-dimethoxyphenylethylamine with phenylacetyl chloride.

[0298] LC-MS: rt=4.5 min, 300 (M+1, ES+).

[0299] N-[2(3-methoxy-isopropoxy-phenyl)-ethyl]-3,4-dimethoxyphenyl-acetamide:

[0300] prepared by reaction of 3-methoxy-4-isopropoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0301] LC-MS: rt=4.2 min, 388 (M+1, ES+).

[0302] N-[2-3,4,5-Trimethoxy-phenyl)ethyl]-3,4-dimethoxyphenyl-acetamide:

[0303] prepared by reaction of 3,4,5-trimethoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0304] LC-MS: rt=3.8 min, 390 (M+1, ES+).

[0305] N-[2-2,3,4-Trimethoxy-phenyl)-ethyl]-3,4-dimethoxyphenyl-acetamide:

[0306] prepared by reaction of 2,3,4-trimethoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0307] LC-MS: rt=4.1 min, 390 (M+1, ES+).

[0308] N-[2-(3-Dimethoxy-phenyl)ethyl]-3,4-dimethoxyphenyl-acetamide:

[0309] prepared by reaction of 3,5-timethoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0310] LC-MS: rt=4.2 min, 360 (M+1, ES+).

[0311] N-[2-3-Benzyloxy-4-methoxy-phenyethyl]-3,4-dimethoxyphenyl-acetamide:

[0312] prepared by reaction of 3-benzyloxy-4-methoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0313] LC-MS: rt=4.7 min, 436 (M+1, ES+), 434 (M−1, ES−).

[0314] N-[2-(4-(Benzyloxy-3-methoxy-phenyl)ethyl]-3,4-dimethoxyphenyl-acetamide:

[0315] prepared by reaction of 4-benzyloxy-3-methoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0316] LC-MS: rt=4.8 min, 436 (M+1, ES+).

[0317] N-[2-(2-Benzyloxy-5-methoxy-phenyl)ethyl]-3,4-dimethoxyphenyl-acetamide:

[0318] prepared by reaction of 2-benzyloxy-5-methoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0319] LC-MS: rt=4.8 min, 436 (M+1, ES+).

[0320] N-[2-(5-Benzyloxy-2-methoxy-phenyl)-ethyl]-3,4-dimethoxyphenyl-acetamide:

[0321] prepared by reaction of 5-benzyloxy-2-methoxyphenylethylamine with 3,4-dimethoxyphenyl acetyl chloride.

[0322] LC-MS: rt=4.9 min, 436 (M+1, ES+).

[0323] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-benzyloxy-acetamide:

[0324] prepared by reaction of 3,4-dimethoxyphenylethylamine with benzyloxy acetyl chloride.

[0325] LC-MS: rt=4.2 min, 330 (M+1, ES+).

[0326] Procedure II:

[0327] A solution of the respective phenylethylamine (25.0 mmol) and the respective phenylacetic acid (25.0 mmol) in 100 mL toluene was refluxed for 24 h in the presence of a Dean-Stark. The solvent was removed in vacuo and the residue was either recrystalized from toluene or purified by flash chromatography to give the following amides:

[0328] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4-methylenedioxyphenyl-acetamide:

[0329] prepared by reaction of 3,4-dimethoxyphenylethylamine and 3,4-methylenedioxyphenylacetic acid.

[0330] LC-MS: rt=4.1 min, 344 (M+1, ES+).

[0331] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-dimethylaminophenyl-acetamide:

[0332] prepared by reaction of 3,4-dimethoxyphenylethylamine and 4-dimethyl-aminophenylacetic acid.

[0333] LC-MS: rt=3.1 min, 343 (M+1, ES+).

[0334] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-fluorophenyl-acetamide:

[0335] prepared by reaction of 3,4-dimethoxyphenylethylamine and 4-fluorophenyl-acetic acid.

[0336] LC-MS: rt=4.1 min, 318 (M+1, ES+).

[0337] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4-difluorophenyl-acetamide:

[0338] prepared by reaction of 3,4-dimethoxyphenylethylamine and 3,4-difluorophenylacetic acid.

[0339] LC-MS: rt=4.2 min, 336 (M+1, ES+).

[0340] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4,5-trimethoxyphenyl-acetamide:

[0341] prepared by reaction of 3,4-dimethoxyphenylethylamine and 3,4,5-trimethoxyphenylacetic acid.

[0342] LC-MS: rt=3.8 min, 390 (M+1, ES+).

[0343] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,3,4-trimethoxyphenyl-acetamide:

[0344] prepared by reaction of 3,4-dimethoxyphenylethylamine and 2,3,4-trimethoxyphenylacetic acid.

[0345] LC-MS: rt=4.1 min, 390 (M+1, ES+).

[0346] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-naphthalen-2-yl-acetamide:

[0347] prepared by reaction of 3,4-dimethoxyphenylethylamine and 2-naphthylacetic acid.

[0348] LC-MS: rt=4.9 min, 350 (M+1, ES+).

[0349] N-[2-2,5-Dimethoxy-phenyl)-ethyl]-3,4-methylenedioxyphenyl-acetamide:

[0350] prepared by reaction of 2,5-dimethoxyphenylethylamine and 3,4-methylenedioxyphenylacetic acid.

[0351] LC-MS: rt=4.3 min, 344 (M+1, ES+).

[0352] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-hydroxy-3-methoxy-phenyl-acetamide:

[0353] prepared by reaction of 3,4-dimethoxyphenylethylamine and 4-hydroxy-3-methoxy-phenylacetic acid.

[0354] LC-MS: rt=3.6 min, 346 (M+1, ES+), 344 (M−1, ES−).

[0355] N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-benzyloxy-4-methoxy-phenyl-acetamide:

[0356] prepared by reaction of 3,4-dimethoxyphenylethylamine and 3-benzyloxy-4-methoxy-phenylacetic acid.

[0357] LC-MS: rt=4.6 min, 436 (M+1, ES+), 434 (M−1, ES−).

[0358] B.1.2. Synthesis of 1,2,3,4-Tetrahydroisoquinolines via Bischler-Napieralski-reaction (General Procedure):

[0359] To a suspension of the respective acetamide (60 mmol) in acetonitrile (100 mL) was added phosphorus oxychloride (16.2 mL, 177 mmol). The mixture was heated to reflux for 6 h and the solvent was removed in vacuo. The resulting oil was taken up in MeOH (70 mL), evaporated to dryness, dissolved in MeOH (130 mL) and cooled to 0° C. NaBH₄ was added in small (!) portions and the reaction mixture was stirred for 14 h. The solvent was removed in vacuo, dichloromethane (150 mL) and water (100 mL) were added, the phases were separated and the aqueous phase was extracted three times with dichloromethane (100 mL). The combined organic phases were concentrated in vacuo to give the following tetrahydroisoquinolines, which were purified either by flash chromatography or by crystallization as hydrochloride salt:

[0360] 1-(3,4-Dimethoxy-benzyl)6-methoxy-1,2,3,4-tetrahydroisoquinoline:

[0361] prepared by cyclisation of N-[2-(3-Methoxy-phenyl)-ethyl]-3,4-dimethoxyphenyl-acetamide.

[0362] LC-MS: rt=3.1 min, 314 (M+1, ES+).

[0363] 1-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0364] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-phenyl acetamide.

[0365] R_(f) (dichloromethane/methanol 5/1)=0.51.

[0366] LC-MS: rt=3.1 min, 284 (M+1, ES+).

[0367] 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0368] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-methoxyphenyl acetamide.

[0369] LC-MS: rt=3.0 min, 314 (M+1, ES+).

[0370] 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0371] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-methoxyphenyl acetamide.

[0372] LC-MS: rt=3.0 min, 314 (M+1, ES+).

[0373] 1-(2,5-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0374] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,5-dimethoxy-phenyl acetamide.

[0375] LC-MS: rt=3.2 min, 344 (M+1, ES+).

[0376] 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0377] prepared by cyclisation of N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0378] LC-MS: rt=3.3 min, 344 (M+1, ES+).

[0379] 1-(2-Phenyl-ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0380] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-phenyl-propionamide.

[0381] LC-MS: rt=3.2 min, 298 (M+1, ES+).

[0382] 1-(1-Phenyl-propyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-phenyl-butyramide.

[0383] LC-MS: rt=3.3 min 312 (M+1, ES+).

[0384] 1-(Diphenylmethyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0385] prepared by cyclisation of N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-diphenyl acetamide.

[0386] LC-MS: rt=3.7 min, 360 (M+1, ES+).

[0387] 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0388] prepared by cyclisation of N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-2,5-dimethoxy-phenyl acetamide.

[0389] LC-MS: rt=3.6 min, 344 (M+1, ES+).

[0390] 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0391] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-chloro-phenyl acetamide.

[0392] LC-MS: rt=3.2 min, 318 (M+1, ES+).

[0393] 1-Benzyl-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0394] prepared by cyclisation of N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-phenyl acetamide.

[0395] LC-MS: rt=3.4 min, 284 (M+1, ES+).

[0396] 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydro-isoquinoline:

[0397] prepared by cyclisation of N-[2-(3-Methoxy-4-isopropoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0398] LC-MS: rt=3.32 min, 372 (M+1, ES+).

[0399] 1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0400] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4-methylenedioxy-phenyl acetamide.

[0401] LC-MS: rt=3.0 min, 328 (M+1, ES+).

[0402] 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline;

[0403] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-dimethyl-amino-phenyl acetamide.

[0404] LC-MS: rt=2.6 min, 327 (M+1, ES+).

[0405] 1-(4-Fluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0406] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4-fluoro-phenyl acetamide.

[0407] LC-MS: rt=3.1 min, 302 (M+1, ES+).

[0408] 1-(3,4-Difluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline:

[0409] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4-difluoro-phenyl acetamide.

[0410] LC-MS: rt=3.1 min. 320 (M+1, ES+).

[0411] 1-(3,4,5-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0412] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3,4,5-trimethoxy-phenyl acetamide.

[0413] LC-MS: rt=3.0 min, 374 (M+1, ES+).

[0414] 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0415] prepared by cyclisation of N-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0416] LC-MS: rt=3.2 min, 374 (M+1, ES+).

[0417] 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0418] prepared by cyclisation of N-[2-(2,3,4-Trimethoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0419] LC-MS: rt=3.2 min, 374 (M+1, ES+).

[0420] 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0421] prepared by cyclisation of N-[2-(3,5-Dimethoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0422] LC-MS: rt=3.5 min, 344 (M+1, ES+).

[0423] 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0424] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2,3,4-trimethoxy-phenyl acetamide.

[0425] LC-MS: rt=3.2 min, 374 (M+1, ES+).

[0426] 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0427] prepared by cyclisation of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-naphthalen-2-yl acetamide.

[0428] LC-MS: rt=3.6 min, 334 (M+1, ES+).

[0429] 1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0430] prepared by cyclisation of N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-3,4-methylenedioxy-phenyl acetamide.

[0431] LC-MS: rt=3.2 min, 328 (M+1, ES+).

[0432] 1-(3,4-Dimethoxy-benzyl)4-benzyloxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline:

[0433] prepared by cyclisation of N-[2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0434] LC-MS: rt=3.7 min, 420 (M+1, ES+).

[0435] 1-(3,4-Dimethoxy-benzyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydro-isoquinoline:

[0436] prepared by cyclisation of N-[2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0437] LC-MS: rt=3.6 min, 420 (M+1, ES+).

[0438] 1-(3,4-Dimethoxy-benzyl-5-benzyloxy-8-methoxy-1,2,3,4-tetrahydro-isoquinoline:

[0439] prepared by cyclisation of N-[2-(2-Benzyloxy-5-methoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0440] LC-MS: rt=4.1 min, 420 (M+1, ES+).

[0441] 1-(3,4-Dimethoxy-benzyl)-8-benzyloxy-5-methoxy-1,2,3,4-tetrahydro-isoquinoline:

[0442] prepared by cyclisation of N-[2-(5-Benzyloxy-2-methoxy-phenyl)-ethyl]-3,4-dimethoxy-phenyl acetamide.

[0443] LC-MS: rt=3.9 min, 420 (M+1, ES+).

[0444] 1-(4-Hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0445] prepared by cyclisation of N-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-hydroxy-3-methoxy-phenyl acetamide.

[0446] LC-MS: rt=2.8 min, 330 (M+1, ES+).

[0447] 1-(3-Benzyloxy-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0448] prepared by cyclisation of N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-benzyloxy-4-methoxy-phenyl acetamide.

[0449] LC-MS: rt=3.6 min, 420 (M+1, ES+).

[0450] 1-Benzyloxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline:

[0451] prepared by cyclisation of N-[2-(3,4-dimethoxy-phenyl)-ethyl]-benzyloxy-acetamide.

[0452] B.2. Alkylation of 1,2,3,4-Tetrahydroisoquinolines with 2-Bromo-acetamides (General Procedure)

[0453] At −15° C. a solution of the respective amine in THF (250 μL, 0.40 M) was added to a solution of 2-bromoacetyl bromide in THF (500 μL, 0.20 M). The reaction mixture was treated with a solution of diisopropylethylamine in THF (250 μL, 2.0 M), allowed to warm up to room temperature and stirred for 30 min. A solution of the respective tetrahydroisoquinoline in DMSO (500 μL, 0.20 M) was added and the mixture was heated to 75° C. for 18 h. After cooling to room temperature water (2.0 mL) and ethyl acetate (2.0 mL) were added, the phases were separated and the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were concentrated in vacuo to give the following tetrahydroisoquinoline derivatives:

Example 17

[0454] 2-(1-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-methyl-benzyl)-acetamide:

[0455] prepared by reaction of 1-Benzyl-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methylbenzylamine

[0456] LC-MS: rt=4.6 min, 385 (M+1, ES+).

Example 18

[0457] 2-(1-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-chloro-benzyl)-acetamide:

[0458] prepared by reaction of 1-Benzyl-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-chlorobenzylamine

[0459] LC-MS: rt=4.7 min, 405 (M+1, ES+).

Example 19

[0460] 2-(1-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-N-(1-naphthalen-1-yl-ethyl)-acetamide:

[0461] prepared by reaction of 1-Benzyl-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-naphthaleneethylamine

[0462] LC-MS: rt=4.7 and 4.8 min, 435 (M+1, ES+).

Example 20

[0463] 2-(1-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-N-benzyl-N-methyl-acetamide:

[0464] prepared by reaction of 1-Benzyl-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzylmethylamine

[0465] LC-MS: rt=3.9 min, 385 (M+1, ES+).

Example 21

[0466] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0467] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxybenzylamine

[0468] LC-MS: rt=4.0 min, 491 (M+1, ES+).

Example 22

[0469] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0470] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0471] LC-MS: rt=3.9 min, 461 (M+1, ES+).

Example 23

[0472] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methoxy-benzyl)-acetamide:

[0473] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methoxybenzylamine

[0474] LC-MS: rt=3.9 min, 491 (M+1, ES+).

Example 24

[0475] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0476] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-napthalenemethylamine

[0477] LC-MS: rt=4.3 min, 511 (M+1, ES+).

Example 25

[0478] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-benzyl)-acetamide:

[0479] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-methylbenzylamine

[0480] LC-MS: rt=4.1 min, 475 (M+1, ES+).

Example 26

[0481] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0482] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0483] LC-MS: rt=4.2 min, 487 (M+1, ES+).

Example 27

[0484] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0485] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0486] LC-MS: rt=4.3 min, 501 (M+1, ES+).

Example 28

[0487] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0488] prepared by reaction of 1-(3,4-dimethoxy-benzyl)6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-piconylamine

[0489] LC-MS: rt=3.1 min 462 (M+1, ES+).

Example 29

[0490] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-4-yl-methyl)-acetamide:

[0491] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-piconylamine

[0492] LC-MS: rt=3.1 min, 462 (M+1, ES+).

Example 30

[0493] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide:

[0494] prepared by reaction of 1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-fluorobenzylamine

[0495] LC-MS: rt=4.0 min; 479 (M+1, ES+).

Example 31

[0496] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-benzyl-acetamide:

[0497] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0498] LC-MS: rt=3.9 min, 431 (M+1, ES+).

Example 32

[0499] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide:

[0500] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0501] LC-MS: rt=4.2 min, 457 (M+1, ES+).

Example 33

[0502] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0503] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0504] LC-MS: rt=4.3 min, 471 (M+1, ES+).

Example 34

[0505] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(pyridin-3-yl-methyl)-acetamide:

[0506] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-piconylamine

[0507] LC-MS: rt=3.0 min, 432 (M+1, ES+).

Example 35

[0508] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-methyl-benzyl)-acetamide:

[0509] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methylbenzylamine

[0510] LC-MS: rt=4.1 min, 445 (M+1, ES+).

Example 36

[0511] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(2,5-difluoro-benzyl)-acetamide:

[0512] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2,5-difluorobenzylamine

[0513] LC-MS: rt=4.1 min, 467 (M+1, ES+).

Example 37

[0514] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(4-fluoro-benzyl)-acetamide:

[0515] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-fluorobenzylamine

[0516] LC-MS: rt=4.0 min, 449 (M+1, ES+).

Example 38

[0517] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-chloro-benzyl)-acetamide:

[0518] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-chlorobenzylamine

[0519] LC-MS: rt=4.2 min, 465 (M+1, ES+).

Example 39

[0520] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(1-naphthalen-1-yl-ethyl)-acetamide:

[0521] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1-naphthaleneethylamine

[0522] LC-MS: rt=4.3 and 4.4 min, 495 (M+1, ES+).

Example 40

[0523] 2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-benzyl-N-methyl-acetamide:

[0524] prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzylmethylamine

[0525] LC-MS: rt=3.8 min, 445 (M+1, ES+).

Example 41

[0526] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0527] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 2-methoxybenzylamine

[0528] LC-MS: rt=4.0 min, 491 (M+1, ES+).

Example 42

[0529] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0530] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with benzylamine

[0531] LC-MS: rt=3.9 min, 461 (M+1, ES+).

Example 43

[0532] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0533] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0534] LC-MS: rt=4.3 min, 511 (M+1, ES+).

Example 44

[0535] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-benzyl)-acetamide:

[0536] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 3-methyl-benzylamine

[0537] LC-MS: rt=4.1 min, 475 (M+1, ES+).

Example 45

[0538] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0539] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1-Aminoindan

[0540] LC-MS: rt=4.2 min, 487 (M+1, ES+).

Example 46

[0541] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0542] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0543] LC-MS: rt=4.3 min, 501 (M+1, ES+).

Example 47

[0544] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0545] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 3-aminomethyl-pyridine

[0546] LC-MS: rt=3.1 min, 462 (M+1, ES+).

Example 48

[0547] 2-[1-(3-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide:

[0548] prepared by reaction of 1-(3-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 2-fluoro-benzylamine

[0549] LC-MS: rt=4.0 min, 479 (M+1, ES+).

Example 49

[0550] 2-[1-(4-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0551] prepared by reaction of 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with benzylamine

[0552] LC-MS: rt=3.9 min, 461 (M+1, ES+).

Example 50

[0553] 2-[1-(4-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0554] prepared by reaction of 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0555] LC-MS: rt=4.2 min, 511 (M+1, ES+).

Example 51

[0556] 2-[1-(4-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0557] prepared by reaction of 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1-Aminoindan

[0558] LC-MS: rt=4.1 min, 487 (M+1, ES+).

Example 52

[0559] 2-[1-(4-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0560] prepared by reaction of 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0561] LC-MS: rt=4.2 min, 501 (M+1, ES+).

Example 53

[0562] 2-[1-(4-Methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide:

[0563] prepared by reaction of 1-(4-Methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with 2-fluoro-benzylamine

[0564] LC-MS: rt=3.9 min, 479 (M+1, ES+).

Example 54

[0565] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0566] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxybenzylamine

[0567] LC-MS: rt=3.7 min, 521 (M+1, ES+).

Example 55

[0568] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methoxy-benzyl)-acetamide:

[0569] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methoxybenzylamine

[0570] LC-MS: rt=3.7 min, 521 (M+1, ES+).

Example 56

[0571] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-benzyl)-acetamide:

[0572] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-methylbenzylamine

[0573] LC-MS: rt=3.8 min, 505 (M+1, ES+).

Example 57

[0574] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0575] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0576] LC-MS: rt=3.9 min. 517 (M+1, ES+).

Example 58

[0577] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-benzyl)-acetamide:

[0578] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methylbenzylamine

[0579] LC-MS: rt=3.8 min, 505 (M+1, ES+).

Example 59

[0580] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0581] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0582] LC-MS: rt=4.0 min, 531 (M+1, ES+).

Example 60

[0583] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0584] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-piconylamine

[0585] LC-MS: rt=2.9 min, 492 (M+1, ES+).

Example 61

[0586] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-4-yl-methyl)-acetamide:

[0587] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-piconylamine

[0588] LC-MS: rt=2.9 min, 492 (M+1, ES+).

Example 62

[0589] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-phenyl-acetamide:

[0590] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with aniline

[0591] LC-MS: rt=3.7 min, 477 (M+1, ES+).

Example 63

[0592] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide:

[0593] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-fluorobenzylamine

[0594] LC-MS: rt=3.7 min, 509 (M+1, ES+).

Example 64

[0595] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[2-(4-methoxy-phenyl)-ethyl]-acetamide:

[0596] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methoxyphenylethylamine

[0597] LC-MS: rt=3.8 min, 535 (M+1, ES+).

Example 65

[0598] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-benzyl)-acetamide:

[0599] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methylbenzylamine

[0600] LC-MS: rt=3.9 min, 505 (M+1, ES+).

Example 66

[0601] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-trifluoromethyl-benzyl)-acetamide:

[0602] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-trifluorobenzylamine

[0603] LC-MS: rt=4.0 min, 559 (M+1, ES+).

Example 67

[0604] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2,5-difluoro-benzyl)-acetamide:

[0605] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2,5-difluorobenzylamine

[0606] LC-MS: rt=3.8 min, 527 (M+1, ES+).

Example 68

[0607] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-fluoro-benzyl)-acetamide:

[0608] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-fluorobenzylamine

[0609] LC-MS: rt=3.8 min, 509 (M+1, ES+).

Example 69

[0610] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-chloro-benzyl)-acetamide:

[0611] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-chlorobenzylamine

[0612] LC-MS: rt=3.9 min, 525 (M+1, ES+).

Example 70

[0613] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2,4-dimethoxy-benzyl)-acetamide:

[0614] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2,4-dimethoxybenzylamine

[0615] LC-MS: rt=3.8 min, 551 (M+1, ES+).

Example 71

[0616] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1-phenyl-ethyl)-acetamide:

[0617] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-phenylethylamine

[0618] LC-MS: rt=3.7 min, 505 (M+1, ES+).

Example 72

[0619] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1-naphthalen-1-yl-ethyl)-acetamide:

[0620] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-naphthaleneethylamine

[0621] LC-MS: rt=4.0 min, 555 (M+1, ES+).

Example 73

[0622] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0623] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzylmethylamine

[0624] LC-MS: rt=3.6 min. 505 (M+1, ES+).

Example 74

[0625] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-furan-2-yl-methyl-acetamide:

[0626] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-aminomethylfurane

[0627] LC-MS: rt=3.5 min, 481 (M+1, ES+).

Example 75

[0628] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-but-2-yl-acetamide:

[0629] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-butylamine

[0630] LC-MS: rt=0.57 min, 457 (M+1, ES+).

Example 76

[0631] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0632] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0633] LC-MS: rt=0.46 min, 492 (M+1, ES+).

Example 77

[0634] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methoxy-indan-1-yl)-acetamide:

[0635] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-4-methoxy-indane

[0636] LC-MS: rt=0.71 min, 547 (M+1, ES+).

Example 78

[0637] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5,7-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0638] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 5,7-dimethyl-1,2,3,4-tetrahydro-1-naphthylamine

[0639] LC-MS: rt=0.80 min, 559 (M+1, ES+).

Example 79

[0640] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0641] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methyl-1,2,3,4-tetrahydro-1-naphthylamine

[0642] LC-MS: rt=0.76 min, 545 (M+1, ES+).

Example 80

[0643] 2-[1-(3,4-Dimethoxy-benzyl)6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide:

[0644] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-6-methoxy-indane

[0645] LC-MS: rt=0.72 min, 547 (M+1, ES+).

Example 81

[0646] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide:

[0647] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-6-methyl-indane

[0648] LC-MS: rt=0.74 min, 531 (M+1, ES+).

Example 82

[0649] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-fluoro-indan-1-yl)-acetamide:

[0650] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-5-fluoro-indane

[0651] LC-MS: rt=0.72 min, 535 (M+1, ES+).

Example 83

[0652] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-methoxy-indan-1-yl)-acetamide:

[0653] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-5-methoxy-indane

[0654] LC-MS: rt=0.75 min, 547 (M+1, ES+).

Example 84

[0655] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-indan-1-yl)-acetamide:

[0656] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-4-methyl-indane

[0657] LC-MS: rt=0.86 min, 531 (M+1, ES+).

Example 85

[0658] 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-indan-1-yl)-acetamide:

[0659] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-3-methyl-indane

[0660] LC-MS: rt=0.85 min, 531 (M+1, ES+).

Example 86

[0661] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide:

[0662] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S)-1-amino-indane

[0663] LC-MS: rt=3.8 min, 517 (M+1, ES+).

Example 87

[0664] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R)-indan-1-yl]-acetamide:

[0665] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R)-1-amino-indane

[0666] LC-MS: rt=3.9 min, 517 (M+1, ES+).

Example 88

[0667] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0668] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0669] LC-MS: rt=4.0 min, 531 (M+1, ES+).

Example 89

[0670] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0671] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0672] LC-MS: rt=3.7 min, 491 (M+1, ES+).

Example 90

[0673] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0674] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0675] LC-MS: rt=4.0 min, 541 (M+1, ES+).

Example 91

[0676] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0677] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzylamine

[0678] LC-MS: rt=3.7 min, 521 (M+1, ES+).

Example 92

[0679] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0680] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[0681] LC-MS: rt=4.0 min, 535 (M+1, ES+).

Example 93

[0682] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0683] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methylamine

[0684] LC-MS: rt=3.7 min, 505 (M+1, ES+).

Example 94

[0685] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0686] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0687] LC-MS: rt=3.5 min, 533 (M+1, ES+).

Example 95

[0688] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[0689] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[0690] LC-MS: rt=3.5 min, 533 (M+1, ES+).

Example 96

[0691] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0692] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0693] LC-MS: rt=3.1 min, 492 (M+1, ES+).

Example 97

[0694] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-11-isoquinolin-2-yl]-N-(2-phenyl-ethyl)-acetamide:

[0695] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-phenyl-ethylamine

[0696] LC-MS: rt=3.8 min, 505 (M+1, ES+).

Example 98

[0697] 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(cyclohexyl-methyl)-acetamide:

[0698] prepared by reaction of (1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with cyclohexyl-methylamine

[0699] LC-MS: rt=4.0 min, 497 (M+1, ES+).

Example 99

[0700] 2-[1-(2,5-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methoxy-benzyl)-acetamide:

[0701] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methoxybenzylamine

[0702] LC-MS: rt=3.9 min. 521 (M+1, ES+).

Example 100

[0703] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0704] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxybenzylamine

[0705] LC-MS: rt=4.3 min, 521 (M+1, ES+).

Example 101

[0706] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0707] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4,-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0708] LC-MS: rt=4.3 min, 491 (M+1, ES+).

Example 102

[0709] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide:

[0710] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3,4-dimethoxyphenylethylamine

[0711] LC-MS: rt=4.3 min, 565 (M+1, ES+).

Example 103

[0712] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0713] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0714] LC-MS: rt=4.5 min, 517 (M+1, ES+).

Example 104

[0715] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0716] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-picolylamine

[0717] LC-MS: rt=3.4 min, 492 (M+1, ES+).

Example 105

[0718] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1-isoquinolin-2-yl]-N-butyl-acetamide:

[0719] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with n-butylamine

[0720] LC-MS: rt=4.2 min, 457 (M+1, ES+).

Example 106

[0721] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide:

[0722] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-fluorobenzylamine

[0723] LC-MS: rt=4.4 min, 509 (M+1, ES+).

Example 107

[0724] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0725] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0726] LC-MS: rt=3.7 min, 492 (M+1, ES+).

Example 108

[0727] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[1,3,4]thiadiazol-2-yl-acetamide:

[0728] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-1,3,4-thiadiazole

[0729] LC-MS: rt=3.8 min, 485 (M+1, ES+).

Example 109

[0730] 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1H-benzoimidazol-2yl-methyl)-acetamide:

[0731] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-(aminomethyl)-benzimidazole

[0732] LC-MS: rt=3.4 min, 531 (M+1, ES+).

Example 110

[0733] 2-[1-(2-Phenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide:

[0734] prepared by reaction of 1-(2-Phenyl-ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 3-picolylamine

[0735] LC-MS: rt=2.7 min, 446 (M+1, ES+).

Example 111

[0736] 2-[1-(2-Phenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-fluoro-benzyl)-acetamide:

[0737] prepared by reaction of 1-(2-Phenyl-ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-fluorobenzylamine

[0738] LC-MS: rt=4.0 min, 463 (M+1, ES+).

Example 112

[0739] 2-[1-(2-Phenyl-ethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-cyclohexyl-acetamide:

[0740] prepared by reaction of 1-(2-Phenyl-ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with cyclohexylamine

[0741] LC-MS: rt=4.0 min, 437 (M+1, ES+).

Example 113

[0742] 2-[1-(1-Phenyl-propyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0743] prepared by reaction of 1-(1-Phenyl-propyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0744] LC-MS: rt=4.4 min, 459 (M+1, ES+).

Example 114

[0745] 2-[1-(1-Phenyl-propyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0746] prepared by reaction of 1-(1-Phenyl-propyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0747] LC-MS: rt=3.7 min, 460 (M+1, ES+).

Example 115

[0748] 2-[1-(Diphenyl-methyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0749] prepared by reaction of 1-(Diphenyl-methyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzylamine

[0750] LC-MS: rt=5.2 min, 537 (M+1, ES+).

Example 116

[0751] 2-[1-(Diphenyl-methyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0752] prepared by reaction of 1-(Diphenyl-methyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0753] LC-MS: rt=4.3 min, 508 (M+1, ES+).

Example 117

[0754] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0755] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0756] LC-MS: rt=4.6 min, 517 (M+1, ES+).

Example 118

[0757] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0758] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0759] LC-MS: rt=4.4 min, 491 (M+1, ES+).

Example 119

[0760] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0761] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzyl-amine

[0762] LC-MS: rt=4.5 min, 521 (M+1, ES+).

Example 120

[0763] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0764] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzyl-amine

[0765] LC-MS: rt=4.6 min, 535 (M+1, ES+).

Example 121

[0766] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0767] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0768] LC-MS: rt=4.1 min, 533 (M+1, ES+).

Example 122

[0769] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[0770] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[0771] LC-MS: rt=4.1 min, 533 (M+1, ES+).

Example 123

[0772] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0773] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0774] LC-MS: rt=3.8 min, 492 (M+1, ES+).

Example 124

[0775] 2-[1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-2-yl)-acetamide:

[0776] prepared by reaction of 1-(2,5-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-indane

[0777] LC-MS: rt=4.6 min, 517 (M+1, ES+).

Example 125

[0778] 2-[1-(4-Chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0779] prepared by reaction of 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0780] LC-MS: rt=4.8 min, 491 (M+1, ES+).

Example 126

[0781] 2-[1-(4-Chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0782] prepared by reaction of 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0783] LC-MS: rt=4.4 min. 465 (M+1, ES+).

Example 127

[0784] 2-[1-(4-Chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0785] prepared by reaction of 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[0786] LC-MS: rt=4.7 min, 509 (M+1, ES+).

Example 128

[0787] 2-[1-(4-Chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0788] prepared by reaction of 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0789] LC-MS: rt=4.0 min, 507 (M+1, ES+), 505 (M−1, ES−).

Example 129

[0790] 2-[1-(4-Chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0791] prepared by reaction of 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0792] LC-MS: rt=3.6 min, 466 (M+1, ES+).

Example 130

[0793] 2-[1-(4-Chloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-2-yl)-acetamide:

[0794] prepared by reaction of 1-(4-Chloro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-indane

[0795] LC-MS: rt=4.5 min, 491 (M+1, ES+).

Example 131

[0796] 2-(1-Benzyl-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[(1S,2R)-2-hydroxy-indan-1-yl)-acetamide:

[0797] prepared by reaction of 1-Benzyl-5,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[0798] LC-MS: rt=4.2 min, 473 (M+1, ES+).

Example 132

[0799] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide:

[0800] prepared by reaction of 1-3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S)-1-amino-indane

[0801] LC-MS: rt=4.1 min, 545 (M+1, ES+).

Example 133

[0802] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0803] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0804] LC-MS: rt=4.3 min, 559 (M+1, ES+).

Example 134

[0805] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0806] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0807] LC-MS: rt=3.9 min, 519 (M+1, ES+).

Example 135

[0808] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0809] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0810] LC-MS: rt=4.3 min, 569 (M+1, ES+).

Example 136

[0811] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0812] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzylamine

[0813] LC-MS: rt=4.0 min, 549 (M+1, ES+).

Example 137

[0814] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0815] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[0816] LC-MS: rt=4.2 min, 563 (M+1, ES+).

Example 138

[0817] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R)-indan-1-yl]-acetamide:

[0818] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R)-1-amino-indane

[0819] LC-MS: rt=4.1 min, 545 (M+1, ES+).

Example 139

[0820] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0821] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methyl-amine

[0822] LC-MS: rt=3.9 min, 533 (M+1, ES+).

Example 140

[0823] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-y)-acetamide:

[0824] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0825] LC-MS: rt=4.0 min, 545 (M+1, ES+).

Example 141

[0826] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0827] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0828] LC-MS: rt=3.4 min, 520 (M+1, ES+).

Example 142

[0829] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[0830] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[0831] LC-MS: rt=3.8 min, 561 (M+1, ES+).

Example 143

[0832] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-phenyl-ethyl)-acetamide:

[0833] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-phenyl-ethylamine

[0834] LC-MS: rt=4.0 min, 533 (M+1, ES+).

Example 144

[0835] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-cyclohexyl-methyl-acetamide:

[0836] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with cyclohexyl-methylamine

[0837] LC-MS: rt=4.2 min, 525 (M+1, ES+).

Example 145

[0838] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0839] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 5,7-dimethyl-1,2,3,4-tetrahydro-1-naphthylamine

[0840] LC-MS: rt=0.84 min, 587 (M+1, ES+).

Example 146

[0841] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0842] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methyl-1,2,3,4-tetrahydro-1-naphthylamine

[0843] LC-MS: rt=0.81 min, 573 (M+1, ES+).

Example 147

[0844] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-indan-1-yl)-acetamide:

[0845] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-4-methyl-indane

[0846] LC-MS: rt=0.79 min, 559 (M+1, ES+).

Example 148

[0847] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide:

[0848] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 4-methyl-1,2,3,4-tetrahydro-1-naphthylamine

[0849] LC-MS: rt=0.81 min, 573 (M+1, ES+).

Example 149

[0850] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide:

[0851] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-6-methoxy-indane

[0852] LC-MS: rt=0.77 min, 575 (M+1, ES+).

Example 150

[0853] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide:

[0854] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-6-methyl-indane

[0855] LC-MS: rt=0.80 min. 559 (M+1, ES+).

Example 151

[0856] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-fluoro-indan-1-yl)-acetamide:

[0857] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-5-fluoro-indane

[0858] LC-MS: rt=0.78 min, 563 (M+1, ES+).

Example 152

[0859] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-indan-1-yl)-acetamide:

[0860] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-2-methyl-indane

[0861] LC-MS: rt=0.79 min, 559 (M+1, ES+).

Example 153

[0862] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-methyl-indan-1-yl)-acetamide:

[0863] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-3-methyl-indane

[0864] LC-MS: rt=0.79 min, 559 (M+1, ES+).

Example 154

[0865] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(3-phenyl-indan-1-yl)-acetamide:

[0866] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-3-phenyl-indane

[0867] LC-MS: rt=0.86 min, 621 (M+1, ES+).

Example 155

[0868] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5,6-dimethoxy-indan-1-yl)-acetamide:

[0869] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-5,6-dimethoxy-indane

[0870] LC-MS: rt=0.72 min, 605 (M+1, ES+).

Example 156

[0871] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-methoxy-indan-1-yl)-acetamide:

[0872] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-5-methoxy-indane

[0873] LC-MS: rt=0.76 min, 575 (M+1, ES+).

Example 157

[0874] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-bromo-indan-1-yl)-acetamide:

[0875] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-5-bromo-indane

[0876] LC-MS: rt=0.82 min, 623 (M+1, ES+).

Example 158

[0877] 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)-acetamide:

[0878] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ylamine

[0879] LC-MS: rt=0.81 min, 573 (M+1, ES+).

Example 159

[0880] 2-[1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0881] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0882] LC-MS: rt=4.2 min, 501 (M+1, ES+).

Example 160

[0883] 2-[1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0884] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0885] LC-MS: rt=4.0 min, 475 (M+1, ES+).

Example 161

[0886] 2-[1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0887] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[0888] LC-MS: rt=4.2 min, 519 (M+1, ES+).

Example 162

[0889] 2-[1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0890] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0891] LC-MS: rt=3.7 min, 517 (M+1, ES+), 515 (M−1, ES−).

Example 163

[0892] 2-[1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-2-yl)-acetamide:

[0893] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-indane

[0894] LC-MS: rt=4.1 min, 501 (M+1, ES+).

Example 164

[0895] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0896] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0897] LC-MS: rt=3.7 min, 500 (M+1, ES+).

Example 165

[0898] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0899] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0900] LC-MS: rt=3.9 min, 514 (M+1, ES+).

Example 166

[0901] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0902] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0903] LC-MS: rt=3.5 min, 474 (M+1, ES+).

Example 167

[0904] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0905] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0906] LC-MS: rt=4.0 min, 524 (M+1, ES+).

Example 168

[0907] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0908] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzylamine

[0909] LC-MS: rt=3.6 min, 504 (M+1, ES+).

Example 169

[0910] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0911] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[0912] LC-MS: rt=3.8 min, 518 (M+1, ES+).

Example 170

[0913] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0914] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0915] LC-MS: rt=3.3 min, 516 (M+1, ES+).

Example 171

[0916] 2-[1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-3,4-dihydro-11H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0917] prepared by reaction of 1-(4-Dimethylamino-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0918] LC-MS: rt=2.9 min, 475 (M+1, ES+).

Example 172

[0919] 2-[1-(4-Fluoro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0920] prepared by reaction of 1-(4-Fluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0921] LC-MS: rt=4.3 min, 475 (M+1, ES+).

Example 173

[0922] 2-[1-(4-Fluoro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0923] prepared by reaction of 1-(4-Fluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0924] LC-MS: rt=4.5 min, 489 (M+1, ES+).

Example 174

[0925] 2-[1-(4-Fluoro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0926] prepared by reaction of 1-(4-Fluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[0927] LC-MS: rt=4.3 min, 493 (M+1, ES+).

Example 175

[0928] 2-[1-(4-Fluoro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0929] prepared by reaction of 1-(4-Fluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methylamine

[0930] LC-MS: rt=3.8 min, 463 (M+1, ES+).

Example 176

[0931] 2-[1-(3,4-Difluoro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0932] prepared by reaction of 1-(3,4-Difluoro-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methylamine

[0933] LC-MS: rt=3.9 min, 481 (M+1, ES+).

Example 177

[0934] 2-[1-(3,4,5-Trimethoxy-benzyl)6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0935] prepared by reaction of 1-(3,4,5-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0936] LC-MS: rt=4.0 min, 547 (M+1, ES+).

Example 178

[0937] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0938] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0939] LC-MS: rt=4.5 min, 547 (M+1, ES+).

Example 179

[0940] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0941] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0942] LC-MS: rt=4.7 min, 561 (M+1, ES+).

Example 180

[0943] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0944] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0945] LC-MS: rt=4.4 min, 521 (M+1, ES+).

Example 181

[0946] 2-[1-(3,4-Dimethoxy-benzyl)6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0947] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0948] LC-MS: rt=4.8 min, 571 (M+1, ES+).

Example 182

[0949] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0950] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzyl-amine

[0951] LC-MS: rt=4.4 min, 551 (M+1, ES+).

Example 183

[0952] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0953] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzyl-amine

[0954] LC-MS: rt=4.6 min, 565 (M+1, ES+).

Example 184

[0955] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0956] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methylamine

[0957] LC-MS: rt=4.0 min, 535 (M+1, ES+).

Example 185

[0958] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[0959] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[0960] LC-MS: rt=4.0 min, 563 (M+1, ES+), 561 (M−1, ES−).

Example 186

[0961] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0962] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0963] LC-MS: rt=4.0 min, 563 (M+1, ES+).

Example 187

[0964] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[0965] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[0966] LC-MS: rt=3.7 min, 522 (M+1, ES+).

Example 188

[0967] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-phenyl-ethyl)-acetamide:

[0968] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-phenyl-ethylamine

[0969] LC-MS: rt=4.5 min, 535 (M+1, ES+).

Example 189

[0970] 2-[1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(cyclohexyl-methyl)-acetamide:

[0971] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with cyclohexyl-methylamine

[0972] LC-MS: rt=4.6 min, 527 (M+1, ES+).

Example 190

[0973] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[0974] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[0975] LC-MS: rt=4.3 min. 547 (M+1, ES+).

Example 191

[0976] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[0977] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[0978] LC-MS: rt=4.4 min, 561 (M+1, ES+).

Example 192

[0979] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[0980] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[0981] LC-MS: rt=4.1 min, 521 (M+1, ES+).

Example 193

[0982] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[0983] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[0984] LC-MS: rt=4.5 min, 571 (M+1, ES+).

Example 194

[0985] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[0986] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzyl-amine

[0987] LC-MS: rt=4.2 min, 551 (M+1, ES+).

Example 195

[0988] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[0989] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzyl-amine

[0990] LC-MS: rt=4.3 min. 565 (M+1, ES+).

Example 196

[0991] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[0992] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methyl-amine

[0993] LC-MS: rt=3.9 min, 535 (M+1, ES+).

Example 197

[0994] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[0995] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[0996] LC-MS: rt=3.8 min, 563 (M+1, ES+), 561 (M−1, ES−).

Example 198

[0997] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[0998] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[0999] LC-MS: rt=3.8 min, 563 (M+1, ES+), 561 (M−1, ES−).

Example 199

[1000] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1001] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1002] LC-MS: rt=3.4 min, 522 (M+1, ES+).

Example 200

[1003] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-phenyl-ethyl)-acetamide:

[1004] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-phenyl-ethylamine

[1005] LC-MS: rt=4.2 min, 535 (M+1, ES+).

Example 201

[1006] 2-[1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(cyclohexyl-methyl)-acetamide:

[1007] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with cyclohexyl-methylamine

[1008] LC-MS: rt=4.3 min, 527 (M+1, ES+).

Example 202

[1009] 2-[l-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-2-yl)-acetamide:

[1010] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,6,7-trimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-indane

[1011] LC-MS: rt=4.2 min, 547 (M+1, ES+).

Example 203

[1012] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide:

[1013] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S)-1-amino-indane

[1014] LC-MS: rt=4.4 min, 517 (M+1, ES+).

Example 204

[1015] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R)-indan-1-yl]-acetamide:

[1016] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R)-1-amino-indane

[1017] LC-MS: rt=4.4 min, 517 (M+1, ES+).

Example 205

[1018] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[1019] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[1020] LC-MS: rt=4.5 min, 531 (M+1, ES+).

Example 206

[1021] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1022] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1023] LC-MS: rt=4.2 min, 491 (M+1, ES+).

Example 207

[1024] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[1025] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[1026] LC-MS: rt=4.5 min, 541 (M+1, ES+).

Example 208

[1027] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[1028] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzyl-amine

[1029] LC-MS: rt=4.2 min, 521 (M+1, ES+).

Example 209

[1030] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[1031] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzyl-amine

[1032] LC-MS: rt=4.4 min, 535 (M+1, ES+).

Example 210

[1033] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1034] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1035] LC-MS: rt=4.2 min, 492 (M+1, ES+).

Example 211

[1036] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[1037] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[1038] LC-MS: rt=3.9 min, 533 (M+1, ES+).

Example 212

[1039] 2-[1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[1040] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[1041] LC-MS: rt=3.9 min, 533 (M+1, ES+).

Example 213

[1042] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1043] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[1044] LC-MS: rt=4.1 min, 547 (M+1, ES+).

Example 214

[1045] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[1046] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[1047] LC-MS: rt=4.3 min, 561 (M+1, ES+).

Example 215

[1048] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1049] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1050] LC-MS: rt=3.9 min, 521 (M+1, ES+).

Example 216

[1051] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[1052] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[1053] LC-MS: rt=4.3 min, 571 (M+1, ES+).

Example 217

[1054] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[1055] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzyl-amine

[1056] LC-MS: rt=4.0 min, 551 (M+1, ES+).

Example 218

[1057] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[1058] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzyl-amine

[1059] LC-MS: rt=4.1 min, 565 (M+1, ES+).

Example 219

[1060] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl)-acetamide:

[1061] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[1062] LC-MS: rt=3.7 min, 563 (M+1, ES+), 561 (M−1, ES−).

Example 220

[1063] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-phenyl-ethyl)-acetamide:

[1064] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-phenyl-ethylamine

[1065] LC-MS: rt=4.0 min, 535 (M+1, ES+).

Example 221

[1066] 2-[1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-2-yl)-acetamide:

[1067] prepared by reaction of 1-(2,3,4-Trimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ammo-indane

[1068] LC-MS: rt=4.1 min, 547 (M+1, ES+).

Example 222

[1069] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1070] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[1071] LC-MS: rt=4.8 min, 507 (M+1, ES+).

Example 223

[1072] 2-[1-Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-11H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[1073] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[1074] LC-MS: rt=4.9 min, 521 (M+1, ES+).

Example 224

[1075] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1076] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1077] LC-MS: rt=4.5 min, 481 (M+1, ES+).

Example 225

[1078] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[1079] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[1080] LC-MS: rt=4.8 min, 531 (M+1, ES+).

Example 226

[1081] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[1082] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzyl-amine

[1083] LC-MS: rt=4.5 min, 511 (M+1, ES+).

Example 227

[1084] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[1085] prepared by reaction of 1-Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzyl-amine

[1086] LC-MS: rt=4.7 min, 525 (M+1, ES+).

Example 228

[1087] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-N-methyl-acetamide:

[1088] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with N-benzyl-N-methyl-amine

[1089] LC-MS: rt=4.2 min. 495 (M+1, ES+).

Example 229

[1090] 1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-[1-Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone:

[1091] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydroisoquinoline

[1092] LC-MS: rt=4.3 min, 507 (M+1, ES+).

Example 230

[1093] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1094] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1095] LC-MS: rt=4.4 min, 482 (M+1, ES+).

Example 231

[1096] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[1097] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[1098] LC-MS: rt=4.1 min, 523 (M+1, ES+), 521 (M−1, ES−).

Example 232

[1099] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S,2R)-2-hydroxy-indan-1-yl]-acetamide:

[1100] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1S,2R)-1-amino-2-indanol

[1101] LC-MS: rt=4.1 min, 523 (M+1, ES+), 521 (M−1, ES−).

Example 233

[1102] 2-[1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-2-yl)-acetamide:

[1103] prepared by reaction of 1-(Naphthalen-2-yl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-indane

[1104] LC-MS: rt=4.7 min, 507 (M+1, ES+).

Example 234

[1105] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide:

[1106] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1,2,3,4-tetrahydro-1-naphthylamine

[1107] LC-MS: rt=4.7 min, 579 (M+1, ES+).

Example 235

[1108] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1109] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[1110] LC-MS: rt=4.5 min, 565 (M+1, ES+).

Example 236

[1111] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1112] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1113] LC-MS: rt=4.3 min, 539 (M+1, ES+).

Example 237

[1114] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(naphthalen-1-yl-methyl)-acetamide:

[1115] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with naphthalen-1-yl-methylamine

[1116] LC-MS: rt=4.7 min, 589 (M+1, ES+).

Example 238

[1117] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-ethoxy-benzyl)-acetamide:

[1118] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-ethoxy-benzylamine

[1119] LC-MS: rt=4.6 min, 583 (M+1, ES+).

Example 239

[1120] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1121] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1122] LC-MS: rt=3.6 min, 541 (M+1, ES+).

Example 240

[1123] 2-[1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1R,2S)-2-hydroxy-indan-1-yl]-acetamide:

[1124] prepared by reaction of 1-(3-Bromo-4-methoxy-benzyl)-6,7-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with (1R,2S)-1-amino-2-indanol

[1125] LC-MS: rt=4.0 min 581 (M+1, ES+), 579 (M−1, ES−).

Example 241

[1126] 2-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1127] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1128] LC-MS: rt=3.8 min, 476 (M+1, ES+).

Example 242

[1129] 2-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methoxy-benzyl)-acetamide:

[1130] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methoxy-benzylamine

[1131] LC-MS: rt=4.6 min, 505 (M+1, ES+).

Example 243

[1132] 2-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[1,3,4]thiadiazol-2-yl-acetamide:

[1133] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-1,3,4-thiadiazole

[1134] LC-MS: rt=4.4 min, 469 (M+1, ES+).

Example 244

[1135] 2-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1H-benzoimidazol-2-yl-methyl)-acetamide:

[1136] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-(aminomethyl)-benzimidazole

[1137] LC-MS: rt=3.8 min, 515 (M+1, ES+).

Example 245

[1138] 2-[1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1H-indazol-6-yl)-acetamide:

[1139] prepared by reaction of 1-(3,4-Methylenedioxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 6-aminoindazole

[1140] LC-MS: rt=4.4 min, 501 (M+1, ES+).

[1141] Analogous to the above mentioned procedure, but in larger scale, the following tetrahydroisoquinoline derivatives were synthesized:

Example 246

[1142] 2-[1-(3,4-Dimethoxy-benzyl)-6-benzyloxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1143] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-benzyloxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1144] LC-MS: rt=4.5 min, 567 (M+1, ES+).

Example 247

[1145] 2-[1-(3,4-Dimethoxy-benzyl)-7-benzyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1146] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1147] LC-MS: rt=4.4 min, 567 (M+1, ES+).

[1148] 2-[1-(3,4-Dimethoxy-benzyl)-7-benzyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1149] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[1150] LC-MS: rt=4.5 min, 593 (M+1, ES+).

Example 248

[1151] 2-[1-(3,4-Dimethoxy-benzyl)-5-benzyloxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1152] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5-benzyloxy-8-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1153] LC-MS: rt=4.4 min, 568 (M+1, ES+).

[1154] 2-[1-(3,4-Dimethoxy-benzyl)-8-benzyloxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1155] prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-8-benzyloxy-5-methoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-picolylamine

[1156] LC-MS: rt=4.4 min, 568 (M+1, ES+).

Example 249

[1157] 2-[1-(4-Hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1158] prepared by reaction of 1-(4-Hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1159] LC-MS: rt=3.4 min, 477 (M+1, ES+).

[1160] 2-[1-(3-Benzyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1161] prepared by reaction of 1-(3-Benzyloxy-4-methoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

[1162] LC-MS: rt=4.4 min, 567 (M+1, ES+).

[1163] 2-(1-Benzyloxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide:

[1164] prepared by reaction of 1-Benzyloxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 1-amino-indane

[1165] LC-MS: rt=4.3 min, 487 (M+1, ES+).

[1166] C Coupling of Phenols with Alkylbromides, Heteroarylchlorides, Heteroaryl-methyl-sulfones and Carbamoylchlorides

[1167] C.1 Starting Materials: Deprotection of Benzylic Ethers:

[1168] To a mixture of MeOH (60 mL) and formic acid (11.0 mL) was added Palladium (10% Pd/C, wet, 274 mg). The respective benzylic ether (4.0 mmol) was added portionwise and the mixture was stirred for 40 h. During this period further portions of Pd/C were added until the starting material was consumed. The mixture was filtered, the solvent was removed in vacuo and the residue was purified by flash-chromatography to give the following phenols:

Example 250

[1169] 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1170] prepared by deprotection of 2-[1-(3,4-dimethoxy-benzyl)-6-benzyloxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[1171] LC-MS: rt=3.5 min, 477 (M+1, ES+).

Example 251

[1172] 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1173] prepared by deprotection of 2-[1-(3,4-dimethoxy-benzyl)-7-benzyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

[1174] LC-MS: rt=3.5 min, 477 (M+1, ES+).

Example 252

[1175] 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1176] prepared by deprotection of 2-[1-(3,4-dimethoxy-benzyl)-7-benzyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

[1177] LC-MS: rt=3.7 min, 503 (M+1, ES+), 501 (M−1, ES−).

[1178] 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1179] prepared by deprotection of 2-[1-(3,4-dimethoxy-benzyl)-5-benzyloxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide

[1180] LC-MS: rt=3.2 min, 478 (M+1, ES+), 476 (M−1, ES−).

[1181] 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1182] prepared by deprotection of 2-[1-(3,4-dimethoxy-benzyl)-8-benzyloxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide

[1183] LC-MS: rt=3.3 min, 478 (M+1, ES+), 476 (M−1, ES−).

Example 253

[1184] 2-[1-(3-Hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1185] prepared by deprotection of 2-[1-(3-Benzyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1186] LC-MS: rt=3.5 min, 477 (M+1, ES+), 475 (M−1, ES−).

[1187] 2-(1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide:

[1188] prepared by deprotection of 2-(1-Benzyloxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1yl)-acetamide:

[1189] LC-MS: rt=3.1 min, 397 (M+1, ES+).

[1190] C.2 Alkylation of Phenols with Alkylbromides (General Procedure):

[1191] At RT a solution of the respective phenol in DMF (250 μL, 0.40 M) was added to K₂CO₃ (70 mg). The reaction mixture was treated with a solution of the respective alkyl bromide in DMF (150 μL, 1.00 M, shaken at 100° C. for 90 min and cooled to RT. After addition of another portion of alkyl bromide (150 μL, 1.00 M), shaking (100° C., 90 min) and cooling to RT a solution of triethylamine in THF (250 μL, 2.0 M) was added and the mixture was shaken for 14 h. Water (2.0 mL) and ethyl acetate (2.0 mL) were added, the phases were separated and the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were concentrated in vacuo to give the following tetrahydroisoquinoline derivatives:

Example 254

[1192] 2-[1-(3,4-dimethoxy-benzyl)-6-ethoxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1193] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl iodide

[1194] LC-MS: rt=3.8 min, 505 (M+1, ES+).

Example 255

[1195] 2-[1-(3,4-dimethoxy-benzyl)-6-propoxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1196] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with propyl bromide

[1197] LC-MS: rt=4.1 min, 519 (M+1, ES+).

Example 256

[1198] 2-[1-(3,4-dimethoxy-benzyl)-6-allyloxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1199] prepared by reaction of 2-[l-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with allyl bromide

[1200] LC-MS: rt=4.0 min, 517 (M+1, ES+).

Example 257

[1201] 2-[1-(3,4-dimethoxy-benzyl)-6-(cyclopropyl-methoxy)-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1202] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with cyclopropylmethyl bromide

[1203] LC-MS: rt=4.1 min, 531 (M+1, ES+).

Example 258

[1204] [2-(Benzylcarbamoyl-methyl)-1-(3,4-dimethoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-yloxy]-acetic acid ethyl ester:

[1205] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl bromoacetate

Example 259

[1206] 2-[1-(3,4-dimethoxy-benzyl)-6-(3-fluoro-propoxy)-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1207] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-6-hydroxy-7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 1-bromo-3-fluoro-propane

[1208] LC-MS: rt=4.0 min, 537 (M+1, ES+).

Example 260

[1209] 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1210] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl iodide

[1211] LC-MS: rt=3.8 min, 505 (M+1, ES+).

Example 261

[1212] 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1213] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with propyl bromide

[1214] LC-MS: rt=4.0 min, 519 (M+1, ES+).

Example 262

[1215] 2-[1-(3,4-dimethoxy-benzyl)-7-butoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1216] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with butyl bromide

[1217] LC-MS: rt=4.2 min, 533 (M+1, ES+).

Example 263

[1218] 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1219] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with allyl bromide

[1220] LC-MS: rt=3.9 min, 517 (M+1, ES+).

Example 264

[1221] 2-[1-(3,4-dimethoxy-benzyl)-7-(cyclopropyl-methoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1222] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with cyclopropylmethyl bromide

[1223] LC-MS: rt=4.0 min, 531 (M+1, ES+).

Example 265

[1224] [2-(Benzylcarbamoyl-methyl)-l-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]-acetic acid ethyl ester:

[1225] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl bromoacetate

[1226] LC-MS: rt=4.0 min.

Example 266

[1227] 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1228] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with ethyl iodide

[1229] LC-MS: rt=0.73 min, 531 (M+1, ES+).

Example 267

[1230] 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1231] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with propyl bromide

[1232] LC-MS: rt=0.77 min, 545 (M+1, ES+).

Example 268

[1233] 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1234] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with allyl bromide

[1235] LC-MS: rt=0.75 min, 543 (M+1, ES+).

Example 269

[1236] 2-[1-(3,4-dimethoxy-benzyl)-7-isopropoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1237] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with isopropyl bromide

[1238] LC-MS: rt=0.75 min, 545 (M+1, ES+).

Example 270

[1239] 2-[1-(3,4-dimethoxy-benzyl)-7-butoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1240] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with butyl bromide

[1241] LC-MS: rt=0.81 min, 559 (M+1, ES+).

Example 271

[1242] 2-[1-(3,4-dimethoxy-benzyl)-7-isobutoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1243] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 1-bromo-2-methyl-propane

[1244] LC-MS: rt=0.80 min, 559 (M+1, ES+).

Example 272

[1245] 2-[1-(3,4-dimethoxy-benzyl)-7-(but-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1246] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-bromo-butane

[1247] LC-MS: rt=0.78 min, 559 (M+1, ES+).

Example 273

[1248] 2-[1-(3,4-dimethoxy-benzyl)-7-(cyclopropyl-methoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1249] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with cyclopropyl-methyl bromide

[1250] LC-MS: rt=0.76 min, 557 (M+1, ES+).

Example 274

[1251] 2-[1-(3,4-dimethoxy-benzyl)-7-cyclohexyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1252] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with cyclohexyl bromide

[1253] LC-MS: rt=0.82 min, 585 (M+1, ES+).

Example 275

[1254] [2-(Indan-1-ylcarbamoyl-methyl)-1-(3,4-dimethoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-yloxy]-acetic acid methyl ester:

[1255] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with methyl bromoacetate

[1256] LC-MS: rt=0.70 min, 575 (M+1, ES+).

Example 276

[1257] 2-[1-(3,4-dimethoxy-benzyl)-7-(3-fluoro-propoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1258] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 1-bromo-3-fluoro-propane

[1259] LC-MS: rt=0.74 min, 563 (M+1, ES+).

Example 277

[1260] 2-[1-(3,4-dimethoxy-benzyl)-7-(2-fluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1261] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 1-bromo-2-fluoro-ethane

[1262] LC-MS: rt=0.72 min, 549 (M+1, ES+).

Example 278

[1263] 2-[1-(3,4-dimethoxy-benzyl)-7-(2,2-difluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1264] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 1-bromo-2,2-difluoro-ethane

[1265] LC-MS: rt=0.75 min, 567 (M+1, ES+).

Example 279

[1266] 2-[1-(3,4-dimethoxy-benzyl)-5-ethoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1267] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with ethyl iodide

[1268] LC-MS: rt=0.61 min, 506 (M+1, ES+).

Example 280

[1269] 2-[1-(3,4-dimethoxy-benzyl)-5-propoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1270] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with propyl bromide

[1271] LC-MS: rt=0.66 min, 520 (M+1, ES+).

Example 281

[1272] 2-[1-(3,4-dimethoxy-benzyl)-5-allyloxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1273] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with allyl bromide

[1274] LC-MS: rt=0.63 min, 518 (M+1, ES+).

Example 282

[1275] 2-[1-(3,4-dimethoxy-benzyl)-5-isopropoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1276] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with isopropyl bromide

[1277] LC-MS: rt=0.64 min, 520 (M+1, ES+).

Example 283

[1278] 2-[1-(3,4-dimethoxy-benzyl)-5-butoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1279] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with butyl bromide

[1280] LC-MS: rt=0.70 min, 534 (M+1, ES+).

Example 284

[1281] 2-[1-(3,4-dimethoxy-benzyl)-5-isobutoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1282] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 1-bromo-2-methyl-propane

[1283] LC-MS: rt=0.70 min, 534 (M+1, ES+).

Example 285

[1284] 2-[1-(3,4-dimethoxy-benzyl)-5-(but-2-oxy)-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1285] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 2-bromo-butane

[1286] LC-MS: rt=0.68 min, 534 (M+1, ES+).

Example 286

[1287] 2-[1-(3,4-dimethoxy-benzyl)-5-(cyclopropyl-methoxy)-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1288] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with cyclopropyl-methyl bromide

[1289] LC-MS: rt=0.66 min, 532 (M+1, ES+).

Example 287

[1290] 2-[1-(3,4-dimethoxy-benzyl)-5-(3-fluoro-propoxy)-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1291] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 1-bromo-3-fluoro-propane

[1292] LC-MS: rt=0.62 min, 538 (M+1, ES+).

Example 288

[1293] 2-[1-(3,4-dimethoxy-benzyl)-5-(2-fluoro-ethoxy)-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1294] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 1-bromo-2-fluoro-ethane

[1295] LC-MS: rt=0.59 min 524 (M+1, ES+).

Example 289

[1296] 2-[1-(3,4-dimethoxy-benzyl)-5-(2,2-difluoro-ethoxy)-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1297] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-pyridin-2-yl-methyl)-acetamide with 1-bromo-2,2-difluoro-ethane

[1298] LC-MS: rt=0.61 m, 542 (M+1, ES+).

Example 290

[1299] [2-[(Pyridin-2-yl-methyl)-carbamoyl-methyl]-1-(3,4-dimethoxy-benzyl)-8-methoxy-1,2,3,4-tetrahydro-isoquinolin-5-yloxy]-acetic acid methyl ester:

[1300] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-5-hydroxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with methyl bromoacetate

[1301] LC-MS: rt=0.58 min, 550 (M+1, ES+).

Example 291

[1302] 2-[1-(3,4-dimethoxy-benzyl)-8-ethoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1303] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with ethyl iodide

[1304] LC-MS: rt=0.62 min, 506 (M+1, ES+).

Example 292

[1305] 2-[1-(3,4-dimethoxy-benzyl)-8-propoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1306] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with propyl bromide

[1307] LC-MS: rt=0.66 min, 520 (M+1, ES+).

Example 293

[1308] 2-[1-(3,4-dimethoxy-benzyl)-8-allyloxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1309] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with allyl bromide

[1310] LC-MS: rt=0.63 min, 518 (M+1, ES+).

Example 294

[1311] 2-[1-(3,4-dimethoxy-benzyl)-8-isopropoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1312] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with isopropyl bromide

[1313] LC-MS: rt=0.64 min, 520 (M+1, ES+).

Example 295

[1314] 2-[1-(3,4-dimethoxy-benzyl)-8-butoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1315] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-pyridin-2-yl-methyl)-acetamide with butyl bromide

[1316] LC-MS: rt=0.69 min, 534 (M+1, ES+).

Example 296

[1317] 2-[1-(3,4-dimethoxy-benzyl)-8-isobutoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1318] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-pyridin-2-yl-methyl)-acetamide with 1-bromo-2-methyl-propane

[1319] LC-MS: rt=0.69 min, 534 (M+1, ES+).

Example 297

[1320] 2-[1-(3,4-dimethoxy-benzyl)-8-(but-2-oxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1321] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 2-bromo-butane

[1322] LC-MS: rt=0.68 min, 534 (M+1, ES+).

Example 298

[1323] 2-[1-(3,4-dimethoxy-benzyl)-8-(cyclopropyl-methoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1324] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with cyclopropyl-methyl bromide

[1325] LC-MS: rt=0.66 min, 532 (M+1, ES+).

Example 299

[1326] 2-[1-(3,4-dimethoxy-benzyl)-8-cyclohexyloxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1327] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with cyclohexyl bromide

[1328] LC-MS: rt=0.73 min, 560 (M+1, ES+).

Example 300

[1329] 2-[1-(3,4-dimethoxy-benzyl)-8-(3-fluoro-propoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1330] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 1-bromo-3-fluoro-propane

[1331] LC-MS: rt=0.62 min, 538 (M+1, ES+).

Example 301

[1332] 2-[1-(3,4-dimethoxy-benzyl)-8-(2-fluoro-ethoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1333] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide with 1-bromo-2-fluoro-ethane

[1334] LC-MS: rt=0.59 min, 524 (M+1, ES+).

Example 302

[1335] 2-[1-(3,4-dimethoxy-benzyl)-8-(2,2-difluoro-ethoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide:

[1336] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-8-hydroxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-pyridin-2-yl-methyl)-acetamide with 1-bromo-2,2-difluoro-ethane

[1337] LC-MS: rt=0.62 min, 542 (M+1, ES+).

Example 303

[1338] 2-[1-(4-ethoxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1339] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl iodide

[1340] LC-MS: rt=3.9 min, 505 (M+1, ES+).

Example 304

[1341] 2-[1-(4-propoxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1342] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with propyl bromide

[1343] LC-MS: rt=4.2 min, 519 (M+1, ES+).

Example 305

[1344] 2-[1-(4-butoxy-3-methoxy-benzyl)6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1345] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with butyl bromide

[1346] LC-MS: rt=4.4 min, 533 (M+1, ES+).

Example 306

[1347] 2-[1-(4-allyloxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1348] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with allyl bromide

[1349] LC-MS: rt=4.0 min, 517 (M+1, ES+).

Example 307

[1350] 2-[1-(4-isopropoxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1351] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with isopropyl bromide

[1352] LC-MS: rt=4.0 min. 519 (M+1, ES+).

Example 308

[1353] 2-[1-(4-isobutoxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1354] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 1-bromo-2-methyl-propane

[1355] LC-MS: rt=4.5 min, 533 (M+1, ES+).

Example 309

[1356] 2-[1-(4-(cyclopropyl-methoxy)-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1357] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with cyclopropyl-methyl bromide

[1358] LC-MS: rt=4.2 min, 531 (M+1, ES+).

Example 310

[1359] {4-[2-(Benzylcarbamoyl-methyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl]-2-methoxy-phenoxy}-acetic acid ethyl ester

[1360] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl bromoacetate

[1361] LC-MS: rt=3.9 min, 563 (M+1, ES+).

Example 311

[1362] 2-[1-(3-ethoxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1363] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with ethyl iodide

[1364] LC-MS: rt=3.8 min, 505 (M+1, ES+).

Example 312

[1365] 2-[1-(3-propoxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1366] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with propyl bromide

[1367] LC-MS: rt=4.1 min, 519 (M+1, ES+).

Example 313

[1368] 2-[1-(3-allyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1369] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with allyl bromide

[1370] LC-MS: rt=4.0 min, 517 (M+1, ES+).

Example 314

[1371] 2-[1-(3-isopropoxy-4-methoxy-benzyl)6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1372] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with isopropyl bromide

[1373] LC-MS: rt=4.0 min, 519 (M+1, ES+).

Example 315

[1374] 2-[1-(3-butoxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1375] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with butyl bromide

[1376] LC-MS: rt=4.3 min, 533 (M+1, ES+).

Example 316

[1377] 2-{1-[3-(but-2-oxy)4-methoxy-benyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1378] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 2-bromo-butane

[1379] LC-MS: rt=4.2 min, 533 (M+1, ES+).

Example 317

[1380] 2-{1-[3-(cyclopropyl-methoxy)-4-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1381] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with cyclopropyl-methyl bromide

[1382] LC-MS: rt=4.0 min, 531 (M+1, ES+).

Example 318

[1383] 2-{1-[3-(3-fluoro-propoxy)-4-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1384] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 1-bromo-3-fluoro-propane

[1385] LC-MS: rt=3.9 min, 537 (M+1, ES+).

Example 319

[1386] 2-[1-(3,4-dimethoxy-benzyl)-7-(1-methyl-prop-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide:

[1387] At room temperature tert.-butyl 2,2,2-trichloroacetimidate (437 mg, 0.36 mL, 2.0 mmol) was added to a solution of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide (95.3 mg, 0.2 mmol) in dichloromethane (5.0 mL) and cyclohexane (5.0 mL). The reaction mixture was treated with a solution of boron trifluoride diethyl etherate (50 μL, 0.4 mmol) in 10 mL dichloromethane and stirred for 22 h. Another portion of tert.-butyl 2,2,2-trichloroacetimidate (244 mg, 0.20 mL, 1.1 mmol) was added. After stirring for three days a saturated solution of NaHCO₃ (10 mL), water (10 mL) and ethyl acetate (40 mL) were added, the phases were separated and the aqueous phase was extracted three times with ethyl acetate (30 mL). The combined organic phases were concentrated in vacuo and purified by flash-chromatography to give the titled product (80.4 mg, 75%) as pale yellow oil.

[1388] LC-MS: rt=4.2 min, 533 (M+1, ES+).

[1389] C.3 Reaktion of Phenols with Heteroaryl Chlorides or Heteroaryl-methyl Sulfones (General Procedure):

[1390] A solution of the respective heteroaryl chloride or methyl-sulfone in DMF (1.0 mL, 0.20 M) was added to a mixture of the respective phenol (0.15 mmol) and K₂CO₃ (75 mg). The reaction mixture was stirred at 100° C. for 16 h. Water (2.0 mL) and ethyl acetate (2.0 mL) were added, the phases were separated and the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were concentrated in vacuo to give the following tetrahydroisoquinoline derivatives:

Example 320

[1391] 2-{1-[3-(pyrimidin-2-yloxy)-4-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1392] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 2-chloro-pyrimidine

[1393] LC-MS: rt=0.60 min, 555 (M+1, ES+).

Example 321

[1394] 2-{1-[4-(pyrimidin-2-yloxy)-3-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1395] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 2-chloro-pyrimidine

[1396] LC-MS: rt=0.60 min, 555 (M+1, ES+).

Example 322

[1397] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1398] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-chloro-pyrimidine

[1399] LC-MS: rt=3.81 min, 581 (M+1, ES+).

Example 323

[1400] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(5-methoxy-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1401] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-methane-sulfonyl-5-methoxy-pyrimidine

[1402] LC-MS: rt=0.69 min, 611 (M+1, ES+).

Example 324

[1403] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(4,6-dimethyl-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1404] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-methane-sulfonyl-4,6-dimethyl-pyrimidine

[1405] LC-MS: rt=0.70 min, 609 (M+1, ES+).

Example 325

[1406] 2-[1-(3,4-dimethoxy-benzyl-6-methoxy-7-(5-bromo-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1407] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 5-bromo-2-chloro-pyrimidine

[1408] LC-MS: rt=0.74 min, 659 (M+1, ES+).

Example 326

[1409] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(5-methyl-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1410] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-chloro-5-methyl-pyrimidine

[1411] LC-MS: rt=0.68 min, 595 (M+1, ES+).

Example 327

[1412] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(4,6-dimethoxy-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1413] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-methane-sulfonyl-4,6-dimethoxy-pyrimidine

[1414] LC-MS: rt=0.75 min, 641 (M+1, ES+).

Example 328

[1415] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(5-trifluoromethyl-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1416] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-methane-sulfonyl-5-trifluoromethyl-pyrimidine

[1417] LC-MS: rt=0.77 min, 649 (M+1, ES+).

Example 329

[1418] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(5-chloro-pyridin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1419] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2,5-dichloro-pyridine

[1420] LC-MS: rt=0.77 min, 614 (M+1, ES+).

Example 330

[1421] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(5-trifluoromethyl-pyridin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1422] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-chloro-5-trifluoromethyl-pyridine

[1423] LC-MS: rt=0.80 min, 648 (M+1, ES+).

Example 331

[1424] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(4-trifluoromethyl-pyrimidin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1425] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-chloro-4-trifluoromethyl-pyrimidine

[1426] LC-MS: rt=0.77 min, 649 (M+1, ES+).

Example 332

[1427] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(2,6-dimethoxy-pyrimidin-4-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1428] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 4-chloro-2,6-dimethoxy-pyrimidine

[1429] LC-MS: rt=0.76 min, 641 (M+1, ES+).

Example 333

[1430] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(pyrazin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1431] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-chloro-pyrazine

[1432] LC-MS: rt=0.68 min, 581 (M+1, ES+).

Example 334

[1433] 2-[1-(3,4-dimethoxy-benzyl)6-methoxy-7-(thiazol-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1434] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 2-bromo-thiazole

[1435] LC-MS: rt=0.72 min, 586 (M+1, ES+).

[1436] C.4 Reaktion of Phenols with Carbamoylchlorides (General Procedure):

[1437] A solution of the respective phenol (0.20 mmol) and triethylamine (0.30 mL, 2.15 mmol) in THF (1.0 mL) was treated with the respective carbamoylchloride (2.2 mmol) and stirred at reflux for 16 h. Water (2.0 mL) and ethyl acetate (2.0 mL) were added, the phases were separated and the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were concentrated in vacuo to give the following tetrahydroisoquinoline derivatives:

Example 335

[1438] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(N,N-dimethylcarbamoyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1439] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with N,N-dimethylcarbamoyl chloride

[1440] LC-MS: rt=0.74 min, 574 (M+1, ES+).

Example 336

[1441] 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(4-morpholine-carbonyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1442] prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with 4-morpholinecarbonyl chloride

[1443] LC-MS: rt=0.72 min, 616 (M+1, ES+).

Example 337

[1444] 2-{1-[4-Methoxy-3-(N,N-dimethylcarbamoyloxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1445] prepared by reaction of 2-[1-(3-hydroxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with N,N-dimethyl-carbamoyl chloride

[1446] LC-MS: rt=0.62 min, 548 (M+1, ES+).

Example 338

[1447] 2-{1-[3-Methoxy-4-(N,N-dimethylcarbamoyloxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1448] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with N,N-dimethyl-carbamoyl chloride

[1449] LC-MS: rt=0.63 min, 548 (M+1, ES+).

Example 339

[1450] 2-{1-[3-Methoxy-4-(4-morpholine-carbonyloxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide:

[1451] prepared by reaction of 2-[1-(4-hydroxy-3-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide with 4-morpholine-carbonyl chloride

[1452] LC-MS: rt=0.61 min, 590 (M+1, ES+).

[1453] D Coupling of 1-Hydroxymethyl-Substituted Tetrahydroisoquinolines with Nitrogen-Nucleophiles (General Procedure):

[1454] To a solution of 2-(1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide (0.10 mmol) and diisopropylethyl-amine (0.25 mmol) in THF (0.50 mL) was added a solution of methanesulfonyl chloride in THF (0.25 mL, 0.44 M). After 60 min the reaction mixture was treated with a solution of the respective nitrogen-nucleophile in THF (0.25 mL, 0.48 M) and stirred for 18 h. Water (2.0 mL) and ethyl acetate (2.0 mL) were added, the phases were separated and the aqueous phase was extracted two times with ethyl acetate. The combined organic phases were concentrated in vacuo to give the following tetrahydroisoquinoline derivatives:

Example 340

[1455] 2-[1-(5,6-Dimethyl-benzoimidazol-1-ylmethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1456] prepared by reaction of 2-(1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide with 5,6-dimethylbenzimidazole

[1457] LC-MS: rt=0.64 min 525 (M+1, ES+).

Example 341

[1458] 2-[1-(1,2,3,4-Tetrahydroisoquinolin-2-ylmethyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide:

[1459] prepared by reaction of 2-(1-Hydroxymethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(indan-1-yl)-acetamide with 1,2,3,4-tetrahydro-isoquinoline

[1460] LC-MS: rt=0.71 min, 512 (M+1, ES+).

[1461] E. General Procedure for the Preparation of the Isonitrile Derivatives

[1462] Isonitriles (or isocyanides) have been prepared by reaction of the N-alkyl-formamides (formed by reaction of the corresponding amine with formic ethyl ester) with POCl₃.

Abbreviations

[1463] BSA Bovine serum albumine

[1464] CHO Chinese hamster ovary

[1465] DMF Dimethylformamide

[1466] DMSO Dimethylsulfoxide

[1467] ES Electron spray

[1468] FCS Foetal calf serum

[1469] FLIPR Fluorescent imaging plate reader

[1470] HBSS Hank's balanced salt solution

[1471] HEPES 4-(2-Hydroxyethyl)-piperazine-1-ethanesulfonic acid

[1472] MeOH Methanol

[1473] MS Mass spectroscopy

[1474] LC Liquid chromatography

[1475] PyBOP Benzotriazole-1-yl-oxy-tris-pyrrolidino-Phosphoniumhexafluorophosphate

[1476] R_(f) Retention front

[1477] R_(t) retention time

[1478] RT Room temperature

[1479] THF Tetrahydrofuran 

1. Compounds of the general formula (I)

wherein: R¹, R², R³, R⁴ independently represent cyano, nitro, halogen, hydrogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, trifluoromethyl, trifluoromethoxy, cycloalkyloxy, aryloxy, aralkyloxy, heterocyclyloxy, heterocyclylalkyloxy, R¹¹CO—, NR¹²R¹³CO—, R¹²R¹³N—, R¹¹OOC—, R¹¹SO₂NH— or R¹⁴—CO—NH— or R² and R³ together as well as R¹ and R² together and R³ and R⁴ together may form with the phenyl ring a five, six or seven-membered ring containing one or two oxygen atoms; R⁵ represents aryl, aralkyl, lower alkenyl, trifluoromethyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R⁶ represents hydrogen, aryl, aralkyl, lower alkyl, lower alkenyl, trifluoromethyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R⁷ and R⁸ independently represent hydrogen, aryl, aralkyl, lower alkyl, lower alkenyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R⁹ represents aryl, aralkyl, lower alkyl, lower alkenyl, trifluoromethyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R¹⁰ represents hydrogen, aryl, aralkyl, lower alkyl, lower alkenyl, trifluoromethyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R¹¹ represents lower alkyl, aryl, aralkyl, heterocyclyl or heterocyclyl-lower alkyl; R¹² and R¹³ independently represent hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or heterocyclyl-lower alkyl; R¹⁴ represents alkyl, aryl, cycloalkyl, heterocyclyl, R¹²R¹³N— or R¹¹O—. and optically pure enantiomers, mixtures of enantiomers, racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diastereoisomeric racemates, mixture of diastereoisomeric racemates, or meso forms and pharmaceutically acceptable salts thereof.
 2. Compounds of the general formula (II)

wherein: R′¹ and R′² independently represent hydrogen, hydroxy, lower alkoxy or halogen or may form with the phenyl ring a five, six or seven membered-ring containing one or two oxygen atoms, R′³ represents aryl, aralkyl, lower alkenyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R′⁴ represents hydrogen, aryl, aralkyl, lower alkyl, lower alkenyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl; R′⁵ represents aryl, aralkyl, lower alkyl, lower alkenyl, cycloalkyl, heterocyclyl or heterocyclyl-lower alkyl and optically pure enantiomers, mixtures of enantiomers, racemates, optically pure diastereoisomers, mixtures of diastereoisomers, diastereoisomeric racemates, mixture of diastereoisomeric racemates, or meso forms and pharmaceutically acceptable salts thereof.
 3. A compound according to any of claims 1 to 2, selected from the group consisting of 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-(cyclopropyl-methoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-(2-fluoro-ethoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-(2,2-difluoro-ethoxy)-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-ethoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-propoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-allyloxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-8-isopropoxy-5-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-dimethoxy-benzyl)-5-propoxy-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide: 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-naphthalen-1-ylmethyl-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(pyrazin-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(thiazol-2-yloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(5-methoxy-indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-ethoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(4-methyl-indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methoxy-indan-1-yl)-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(6-methyl-indan-1-yl)-acetamide 2-{1-[4-(pyrimidin-2-yloxy)-3-methoxy-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl}-N-benzyl-acetamide 2-[1-(3,4-dimethoxy-benzyl)-6-methoxy-7-(N,N-dimethylcarbamoyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-(3-fluoro-propoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-(2-fluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-(2,2-difluoro-ethoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-(but-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-(cyclopropyl-methoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-isopropoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-(1-methyl-prop-2-oxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide 2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide 2-[(1S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-ethoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-propoxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide 2-[1-(3,4-dimethoxy-benzyl)-7-allyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide N-benzyl-2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide 2-[1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[(1S)-indan-1-yl]-acetamide N-benzyl-2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-acetamide 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide 2-[1-(3,4-Diethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-4-yl-methyl)-acetamide 2-[1-(3,4-Dichloro-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-3-yl-methyl)-acetamide
 4. A process for the combinatorial preparation of compounds of the general formula I, wherein R⁶, R⁷ and R⁹ are hydrogen, by using an Ugi-three-components-condensation reaction, comprising the one pot reaction of a compound of formula III

wherein R₁, R₂, R₃, R₄ and R₅ have the meaning given in formula I above and R₆ represents hydrogen, with a compound of formula IV

wherein R₇ represents hydrogen and R₈ has the meaning given in formula I above, and a compound of formula V

wherein RIO has the meaning given in formula I above, if desired, isolating pharmacologically active compounds in a manner known per se, if desired, resolving a racemate obtained in a manner known per se and, if desired converting a compound or compounds obtained into a salt in a manner known per se.
 5. A process for the preparation of compounds of formula I above, comprising reacting a compound of formula III′,

wherein the substituents R₁ to R₆ have the meaning given in formula I above, with a compound of formula VI

wherein R₇ to R₁₀ have the meaning given in formula I above.
 6. A process for the preparation of compounds of formula I above, comprising reacting a compound of formula III′,

wherein the substituents R₁ to R₆ have the meaning given in formula I above, with a) a compound of formula IX

wherein R₇, R₈ and R₁₁ have the meaning given in formula I above, b) cleaving an ester obtained in a manner known per se and reacting the acid formed with c) a compound of formula X

wherein the substituents R₉ and R₁₀ have the meaning given in formula I above, if desired, resolving a racemate obtained in a manner known per se and, if desired, converting a compound obtained into a salt in a manner known per se.
 7. Pharmaceutical compositions for the treatment of disorders which a associated with the role of orexin, especially disorders such as obesity and sleep disorders, containing a compound of any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, and usual carrier materials and adjuvants.
 8. The compounds of any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, for use as medicaments for the treatment of disorders which are associated with a role of orexin, especially obesity and sleep disorders.
 9. A method of treating or preventing diseases or disorders where an antagonist of a human orexin receptor is required, which comprises administering to a subject in need thereof an effective amount of a compound as claimed in any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof.
 10. A process for the manufacture of pharmaceutical compositions for the treatment of disorders associated with the role of orexin, especially obesity and sleep disorders, containing one or more compounds as claimed in any one of claims 1 to 3, or a pharmaceutically acceptable salt or salts thereof, as active ingredients which process comprises mixing one or more active ingredient or ingredients with pharmaceutically acceptable excipients and adjuvants in a manner known per se.
 11. A compound as described as target compound in any one of examples 1 to
 341. 